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<p>This study evaluates the efficacy of autologous Platelet-Rich Plasma (PRP) in comparison to the conventional method in myringoplasty among 90 patients diagnosed with chronic suppurative otitis media (CSOM). Conducted at a tertiary care hospital in India, the study enrolled adult patients into two equal groups—one receiving PRP with standard myringoplasty and the other undergoing the conventional approach. Pre-operative and post-operative outcomes were assessed using otoendoscopy and pure tone audiometry at one and three months. Statistical analysis revealed that the PRP group exhibited significantly improved hearing, with a greater reduction in the air-bone gap at both follow-up intervals (17.18 dB at one month, 13.52 dB at three months) compared to the control group. Furthermore, graft uptake was significantly superior in the PRP group at three months (97.8% vs. 80%, <i>p</i> = 0.015), suggesting enhanced integration and healing. Although improvements in hearing were not statistically significant in all parameters, the trend favoured PRP. These findings align with similar studies and support the hypothesis that PRP accelerates tissue repair and graft stability. The study concludes that autologous PRP serves as a promising adjunct in myringoplasty, offering superior clinical outcomes and suggesting its potential as a valuable tool in otologic surgery.</p>

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Comparison of the Use of Autologous Platelet Rich Plasma with Conventional Method in Myringoplasty

  • 期刊论文

  • 发表日期：

    2025年10月14日

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  • Rakhee Raghavan,
  • Prasun Mishra,
  • Ankit Raj,
  • Aniruddh Sinha,
  • Somya Maskara

摘要

This study evaluates the efficacy of autologous Platelet-Rich Plasma (PRP) in comparison to the conventional method in myringoplasty among 90 patients diagnosed with chronic suppurative otitis media (CSOM). Conducted at a tertiary care hospital in India, the study enrolled adult patients into two equal groups—one receiving PRP with standard myringoplasty and the other undergoing the conventional approach. Pre-operative and post-operative outcomes were assessed using otoendoscopy and pure tone audiometry at one and three months. Statistical analysis revealed that the PRP group exhibited significantly improved hearing, with a greater reduction in the air-bone gap at both follow-up intervals (17.18 dB at one month, 13.52 dB at three months) compared to the control group. Furthermore, graft uptake was significantly superior in the PRP group at three months (97.8% vs. 80%, p = 0.015), suggesting enhanced integration and healing. Although improvements in hearing were not statistically significant in all parameters, the trend favoured PRP. These findings align with similar studies and support the hypothesis that PRP accelerates tissue repair and graft stability. The study concludes that autologous PRP serves as a promising adjunct in myringoplasty, offering superior clinical outcomes and suggesting its potential as a valuable tool in otologic surgery.