<p>Headache is a very frequent symptom, which is the complaint of half of the patients that come to the physician. Mucosal contact headache is a newly added secondary headache disorder in the International Classification of Headache Disorders-2 (ICHD-2). According to the ICHD-2, these headaches are characterized by intermittent pain localized in the peri-orbital and medial canthal or temporo-zygomatic regions, associated with evidence of mucosal contact points by diagnostic nasal endoscopy (DNE) or computed tomography (CT) imaging. This study was done to evaluate intra nasal contact points as a causal factor of refractory headache and to evaluate the relief in headache using Headache Impact Test (HIT-6) questionnaire after surgical intervention. The present prospective nonrandomized interventional study was conducted in department of otorhinolaryngology and head and neck surgery at Sri Guru Ram Das Institute of Medical Sciences and Research, Sri Amritsar. Sixty patients with refractory headaches and intranasal mucosal contact points on DNE and CT scan were included. All patients underwent a local anaesthetic test for diagnostic confirmation, followed by appropriate surgical interventions were performed. HIT-6 scores were recorded in all patients preoperatively and postoperatively at 3&#xa0;months. Statistical analysis was performed using chi square tests. In our study, septal spur was the most common intranasal contact point. In majority of patients the site of headache was frontal region 44 (73.3%), followed by multicentric headache in 25 (41.7%). Out of 60 patients, 54 patients had complete relief in headache after surgical intervention. Our results suggested that surgical correction of nasal mucosal contact points can be very helpful in a headache which is usually not diagnosed or treated by medical management.</p>