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<p>Benign fibrous histiocytoma (BFH) is a rare soft tissue neoplasm that primarily arises in the skin and subcutaneous tissues, affecting the extremities and trunk. This case report describes a rare instance of benign fibrous histiocytoma (BFH) in the nasal vestibule of a 31-year-old male, presenting with progressive swelling and nasal obstruction. A firm mass was identified on examination, and surgical excision confirmed the diagnosis through histopathology, revealing spindle-shaped cells, vesicular nuclei, scattered foamy histiocytes and multinucleated giant cells. Immunohistochemical analysis showed positivity for CD68, factor XIIIa &amp; CD163, distinguishing it from malignant neoplasms. This case highlights the rarity of BFH in this location and emphasizes the importance of histopathological and immunohistochemical evaluation for accurate diagnosis.</p>

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A Case Report: “Unusual Presentation of Benign Fibrous Histiocytoma in Nasal Vestibule”

  • 期刊论文

  • 发表日期：

    2025年9月10日

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  • P. S. Kishen Khanna,
  • S. Vijayasundaram,
  • Aparna Das,
  • Kavitha Mani,
  • M. Kishor Kannan

摘要

Benign fibrous histiocytoma (BFH) is a rare soft tissue neoplasm that primarily arises in the skin and subcutaneous tissues, affecting the extremities and trunk. This case report describes a rare instance of benign fibrous histiocytoma (BFH) in the nasal vestibule of a 31-year-old male, presenting with progressive swelling and nasal obstruction. A firm mass was identified on examination, and surgical excision confirmed the diagnosis through histopathology, revealing spindle-shaped cells, vesicular nuclei, scattered foamy histiocytes and multinucleated giant cells. Immunohistochemical analysis showed positivity for CD68, factor XIIIa & CD163, distinguishing it from malignant neoplasms. This case highlights the rarity of BFH in this location and emphasizes the importance of histopathological and immunohistochemical evaluation for accurate diagnosis.