<p>Objectives: This study aims to analyse the surgical outcomes and quality of life (QOL) in surgically treated patients of JNA operated via open or endoscopic approach. Materials and methods: 30 patients diagnosed and surgically treated for JNA at AIIMS Rishikesh over a period of 6 years were recruited. It was an observational study wherein University of Washington Quality of Life questionnaire Hindi translated validated version (UW-QoL) was administered to patients to assess the QOL in the immediate post operative period under Physical, Physiological and Psychological domains. Results: The surgical outcomes of endoscopic approach group were comparatively better in terms of complications, intraoperative blood loss, hospital stay and quality of life. The items of ‘Pain’, ‘Appearance’, ‘Speech’, ‘Swallowing’, ‘Chewing’ and ‘Activity’ had significantly better outcomes in the Endoscopic approach, with <i>p</i>-values &lt;0.05. The items of ‘Taste’, ’Saliva’, ‘Mood’, ‘Anxiety’ and ‘Recreation’ had better scores in the Endoscopic approach group; however, the difference was not significant (<i>p</i>-values &gt;0.05). Conclusion: Despite the aggressive nature and extent of surgery entailed in JNA, its effect on QoL has not been well reported. In today’s era, the assessment of surgical outcomes has changed from clinical symptom improvement to improvement in mean physical and mental health. The medical model is shifting from radical to conservative approaches. This study throws insight into the better post-surgical outcomes and QoL via endoscopic approach, thus imparting lesser morbidity, lesser psychological stress, better cosmesis, haemostasis, early restoration of physiological functions of chewing and swallowing in the post-operative period with minimal complications and lesser duration of hospital stay in the young population. It also emphasizes the need of framing a robust questionnaire which will effectively help clinicians to develop new intervention tools towards less morbidity.</p>