Background <p>This study aims to investigate and map the cortical responses to speech stimuli in individuals with Auditory Neuropathy Spectrum Disorder (ANSD) using a 64-channel recording system to better understand cortical processing and topographical mapping of speech perception in this population.</p> Method <p>The study included 30 participants divided into two groups: Group I comprised 15 individuals with normal hearing, and Group II comprised 15 individuals with ANSD. Auditory Late Latency Responses (ALLRs) were recorded for the speech stimulus /da/ using a high-density 64-channel recording system.</p> Results <p>Individuals with ANSD exhibited delayed latencies P1-N1-P2 peaks and reduced N1 amplitude. Significant differences were also observed in the scalp topographical maps between the groups.</p> Conclusion <p>Cortical processing of speech is impaired in individuals with ANSD. Additionally, the differences in scalp topography indicate potential cortical reorganization or compensatory mechanisms for processing auditory information in individuals with ANSD. These findings warrant further investigations into later auditory evoked potentials, to enhance our understanding of the processing of complex speech stimuli in this population.</p>