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<p><b>Introduction:</b> Sinonasal Glomangiopericytoma (GPC) has been cited as a rare low-grade neoplasm affecting the sinonasal tract with an incidence of 0.5 to 1%. It’s histological similarity with other borderline malignant sinonasal tumors but biologically different behavior further adds to the complexity in establishing a correct diagnosis. <b>Case Presentation:</b> We present the case of a Hepatitis-C virus (HCV) positive female in her early 50s who presented with unilateral nasal obstruction, epistaxis, and noisy breathing. Clinical examination revealed the presence of a fleshy mass filling the right nasal cavity with extension into the oropharynx. She underwent emergency tracheostomy. The histopathology was suspicious for glomangiopericytoma. Immunohistochemistry profile was positive for CD56, BCL2, vimentin, TLE1, thus, clinching the diagnosis. The patient was taken up for tumor excision via combined approach. A follow-up period of 6 month showed no clinical evidence of recurrence. <b>Conclusion:</b> Even though indolent, glomangiopericytoma may have an atypical presentation and should be kept as a differential.</p>

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Mysterious Oronasal Mass: Unmasking Glomangiopericytoma

  • 期刊论文

  • 发表日期：

    2025年7月23日

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  • N. Prashanth,
  • Viny Bhardwaj,
  • Abhinav Rathi,
  • Navneeta Gangwar,
  • Naresh N. Rai,
  • Yash Sharma

摘要

Introduction: Sinonasal Glomangiopericytoma (GPC) has been cited as a rare low-grade neoplasm affecting the sinonasal tract with an incidence of 0.5 to 1%. It’s histological similarity with other borderline malignant sinonasal tumors but biologically different behavior further adds to the complexity in establishing a correct diagnosis. Case Presentation: We present the case of a Hepatitis-C virus (HCV) positive female in her early 50s who presented with unilateral nasal obstruction, epistaxis, and noisy breathing. Clinical examination revealed the presence of a fleshy mass filling the right nasal cavity with extension into the oropharynx. She underwent emergency tracheostomy. The histopathology was suspicious for glomangiopericytoma. Immunohistochemistry profile was positive for CD56, BCL2, vimentin, TLE1, thus, clinching the diagnosis. The patient was taken up for tumor excision via combined approach. A follow-up period of 6 month showed no clinical evidence of recurrence. Conclusion: Even though indolent, glomangiopericytoma may have an atypical presentation and should be kept as a differential.