Aim <p>Glandular odontogenic cyst (GOC), a rare and uncommon jawbone cyst of odontogenic origin has a potentially aggressive behavior and a relatively high recurrence rate. The importance of this lesion relates to the fact that along with a high recurrence rate it also shares overlapping histological features with muco-epidermoid carcinoma (MEC). Comprehensive research is the need of the hour to identify the molecular markers specific for GOC. Thus, this present case series reports 6 cases of GOC with clinic-pathologic characteristics along with immunohistochemical expression of various markers.</p> Material and Method <p>This retrospective analysis included six histologically confirmed GOC cases reported at a tertiary care center in Eastern Uttar Pradesh. Clinical, radiological, and histopathological findings were documented. IHC analysis was conducted using Ki-67, MCM3, MUC1 and MUC5AC.</p> Result <p>Ki67, marker of proliferative activity, has been reported to have highest mean proliferative index in cases of GOC and MCM3 the least. MUC1 and MUC5AC did not express any proliferative index as compared to Ki67.</p> Conclusion <p>The findings emphasize the diagnostic utility of Ki-67 and MUC1 in distinguishing GOC from mimicking lesions. Larger prospective studies are warranted to establish robust IHC diagnostic criteria.</p> Clinical Trial Number <p>Not applicable.</p>