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<p>Chronic rhinosinusitis with nasal polyposis (CRSwNP) significantly impacts patients’ quality of life (QOL), yet its correlation with radiological severity remains unclear. This study evaluates the relationship between sinonasal and general well-being QOL measures with radiological scores in CRSwNP patients. A cross-sectional study was conducted at a tertiary care hospital in South India, enrolling 76 adult patients diagnosed with CRSwNP based on EPOS 2020 criteria. Sinonasal symptom severity and general well-being were assessed using the Sino-Nasal Outcome Test-20 (SNOT-20) and the Short Form-36 (SF-36) QOL questionnaire, respectively. Radiological severity was determined using the Lund- Mackay Score (LMS) from preoperative CT scans. Pearson’s and Spearman’s correlation tests analyzed the relationships between QOL scores and radiological findings. A strong negative correlation was observed between SNOT-20 and SF-36 scores (ρ = -0.669, <i>p</i> &lt; 0.001), indicating that patients with worse sinonasal symptoms experienced lower overall QOL. However, LMS showed no significant correlation with either SNOT-20 (ρ = 0.141, <i>p</i> = 0.223) or SF-36 scores (ρ = -0.176, <i>p</i> = 0.127), suggesting that radiological disease severity does not align with patient-reported symptom burden or overall well-being. Among SF-36 subdomains, only physical functioning showed a weak negative correlation with LMS (ρ = -0.304, <i>p</i> = 0.008). Patients with allergies and smoking history had significantly lower SF-36 scores and higher SNOT-20 scores (<i>p</i> &lt; 0.05), whereas education level and prior nasal surgery did not significantly affect QOL outcomes. This study highlights the disconnect between radiological severity and patient-perceived symptom burden in CRSwNP. While SNOT-20 and SF-36 scores are strongly correlated, LMS does not reliably predict QOL outcomes. These findings underscore the need for a patient-centered approach in CRS management, integrating subjective QOL assessments with clinical and radiological evaluations for optimal treatment strategies.</p>

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Correlation of Sinonasal and General Well-Being Quality of Life Tools with Radiological Scores in Chronic Sinusitis with Polyposis

  • 期刊论文

  • 发表日期：

    2025年7月2日

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  • Ramkumar Rethinasamy,
  • Lokesh Kumar Penubarthi,
  • Kalaiarasi Raja,
  • Sivaraman Ganesan,
  • Arun Alexander

摘要

Chronic rhinosinusitis with nasal polyposis (CRSwNP) significantly impacts patients’ quality of life (QOL), yet its correlation with radiological severity remains unclear. This study evaluates the relationship between sinonasal and general well-being QOL measures with radiological scores in CRSwNP patients. A cross-sectional study was conducted at a tertiary care hospital in South India, enrolling 76 adult patients diagnosed with CRSwNP based on EPOS 2020 criteria. Sinonasal symptom severity and general well-being were assessed using the Sino-Nasal Outcome Test-20 (SNOT-20) and the Short Form-36 (SF-36) QOL questionnaire, respectively. Radiological severity was determined using the Lund- Mackay Score (LMS) from preoperative CT scans. Pearson’s and Spearman’s correlation tests analyzed the relationships between QOL scores and radiological findings. A strong negative correlation was observed between SNOT-20 and SF-36 scores (ρ = -0.669, p < 0.001), indicating that patients with worse sinonasal symptoms experienced lower overall QOL. However, LMS showed no significant correlation with either SNOT-20 (ρ = 0.141, p = 0.223) or SF-36 scores (ρ = -0.176, p = 0.127), suggesting that radiological disease severity does not align with patient-reported symptom burden or overall well-being. Among SF-36 subdomains, only physical functioning showed a weak negative correlation with LMS (ρ = -0.304, p = 0.008). Patients with allergies and smoking history had significantly lower SF-36 scores and higher SNOT-20 scores (p < 0.05), whereas education level and prior nasal surgery did not significantly affect QOL outcomes. This study highlights the disconnect between radiological severity and patient-perceived symptom burden in CRSwNP. While SNOT-20 and SF-36 scores are strongly correlated, LMS does not reliably predict QOL outcomes. These findings underscore the need for a patient-centered approach in CRS management, integrating subjective QOL assessments with clinical and radiological evaluations for optimal treatment strategies.