Introduction <p>Chronic Rhinosinusitis (CRS) is a disease characterized by persistent inflammation of the nasal and paranasal sinuses. It is well known that using hypertonic saline, diluted betadine saline, and normal saline improves mucociliary clearance¹. This study aimed to compare efficacy of 3% hypertonic saline nasal irrigation against 0.5% diluted betadine saline nasal irrigation in the postoperative period sinonasal outcome (SNOT 22) questionnaire.</p> Objective <p>To assess the impact of 3% hypertonic saline and 0.5% betadine solution nasal irrigation” on the “QUALITY OF LIFE” using the sinonasal outcome (SNOT 22) questionnaire.</p> Methodology <p>A one year study with a sample size of 102 (51 in each group) assess the impact of 3% hypertonic saline and 0.5% betadine solution nasal irrigation” on the “QUALITY OF LIFE” at 1st week, 1st month and 3rd month.</p> Results <p>The study showed significant difference at the end of 1st week and 1st month in both groups proving betadine solution to be slightly better whereas in the 3rd month the hypertonic saline showed better results.</p> Conclusion <p>This study concludes that that both 0.5% betadine solution and 3% hypertonic saline are equally significant with 3% hypertonic saline having slightly better results, where 0.5% diluted betadine solution has proven to be slightly better in the short-term treatment up to 1 month, and 3% hypertonic saline proved to be better in a long-term treatment upto 3 months.</p>