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<p>Desmoid tumors affecting vital structures can be life-threatening despite their non-malignant behavior. The lack of standardized treatment poses a therapeutic challenge, particularly regarding the sequelae in pediatric patients. A one-month-old male patient presented with respiratory distress and stridor. Endoscopic exploration and computed tomography revealed a laryngeal tumor, which was confirmed as a desmoid tumor via biopsy. Systemic chemotherapy in combination with imatinib was initiated, leading to stabilization of the tumor size. A surgical approach for desmoid tumors may be unsuitable for pediatric patients due to excessive morbidity. In such cases, targeted therapies like tyrosine kinase inhibitors can effectively control the disease.</p>

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Congenital Desmoid Tumor of the Larynx: A Therapeutic Challenge

  • 期刊论文

  • 发表日期：

    2025年6月9日

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  • Saúl Astray Gómez,
  • Santiago Almanzo,
  • Adrián Hernández Moya,
  • Agustín Alamar Velázquez,
  • Miguel Armengot Carceller

摘要

Desmoid tumors affecting vital structures can be life-threatening despite their non-malignant behavior. The lack of standardized treatment poses a therapeutic challenge, particularly regarding the sequelae in pediatric patients. A one-month-old male patient presented with respiratory distress and stridor. Endoscopic exploration and computed tomography revealed a laryngeal tumor, which was confirmed as a desmoid tumor via biopsy. Systemic chemotherapy in combination with imatinib was initiated, leading to stabilization of the tumor size. A surgical approach for desmoid tumors may be unsuitable for pediatric patients due to excessive morbidity. In such cases, targeted therapies like tyrosine kinase inhibitors can effectively control the disease.