Mantle Cell Lymphoma in the Oral Cavity: Exploring the Differential Microscopic Diagnosis of a Rare Case

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发表日期：

2024年7月3日

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Moisés Willian Aparecido Gonçalves,
Luccas Lavareze,
Carlos Takahiro Chone,
Erika Said Abu Egal,
Albina Altemani,
Fernanda Viviane Mariano,
Leandro Luiz Lopes de Freitas

摘要

Mantle cell lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin’s lymphoma (NHL), which generally has an aggressive course. Its pathophysiology seems to be related with the malignant transformation of B-cell mantle zone lymphocytes due to the CCND1 rearrangement. The occurrence of MCL in the oral cavity is especially rare. In this report, we present an exceptional case of oral MCL diagnosed in the palate in a 56-year-old male patient, highlighting its distinct morphological and immunohistochemical features that may assist in the accurate diagnosis.