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<p>The journey of warfarin started way back in the 1920s from a haemorrhagic cattle disease caused by the consumption of moudy clover hay. After extensive research by Professor Link and his team to identify the substance responsible for the bleeding in cows, a compound named dicoumarol was isolated, eventually leading to the discovery of warfarin. Despite its initial popularity as a rat killer, it was proven to be effective in treating blood clots in human patients. Globally, it has been the most widely used oral anticoagulant since the 1950s. The fact that it inhibits the vitamin K-dependent clotting factors has opened new opportunities in the field of cardiovascular drugs.</p>

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Serendipitous Discovery of Warfarin

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • Santarupa Thakurta

摘要

The journey of warfarin started way back in the 1920s from a haemorrhagic cattle disease caused by the consumption of moudy clover hay. After extensive research by Professor Link and his team to identify the substance responsible for the bleeding in cows, a compound named dicoumarol was isolated, eventually leading to the discovery of warfarin. Despite its initial popularity as a rat killer, it was proven to be effective in treating blood clots in human patients. Globally, it has been the most widely used oral anticoagulant since the 1950s. The fact that it inhibits the vitamin K-dependent clotting factors has opened new opportunities in the field of cardiovascular drugs.