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<p>A green and efficient protocol for the synthesis of cyanoacetic esters from cyanoacetic acid and various alcohols with excellent yields (up to 91%) has been demonstrated using 5 mol% Zn<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> as a nanocatalyst. Subsequently, using the same nanocatalyst, various substituted electrophilic alkenes and coumarin derivative have been synthesized in good to excellent yields (up to 95%) via Knoevenagel condensation in water as green solvent. The nanocatalyst has been efficiently utilized to synthesize substituted electrophilic alkenes via sequential esterification and Knoevenagel condensation under one-pot green and aqueous conditions. The developed protocol has several advantages including green reaction conditions, operationally simple, high yields and selectivity of products, cost-effectiveness, and nanocatalyst is easily synthesizable, efficient, nontoxic, recoverable and recyclable.</p> Graphical abstract <p>An efficient green protocol for the synthesis of cyanoacetic esters, substituted electrophilic alkenes and coumarin derivative have been developed using 5 mol% Zn<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> as recoverable and recyclable nanocatalyst. The same nanocatalyst has been efficiently utilized to synthesize substituted electrophilic alkenes via sequential esterification and Knoevenagel condensation under one-pot reaction conditions.</p> <p></p>

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Green and efficient approach for the synthesis of cyanoacetic esters and substituted electrophilic alkenes using Zn3(PO4)2 as a nanocatalyst

  • 期刊论文

  • 发表日期：

    2026年4月21日

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  • Swatantra Agrawal,
  • Pankaj Lal Kalar,
  • Priyanka Ahirwar,
  • Sachin Kumar Ben,
  • Shubham Som,
  • Deepak Chopra,
  • Krishna Kumar Raj,
  • Vimlesh Chandra,
  • Kalpataru Das

摘要

A green and efficient protocol for the synthesis of cyanoacetic esters from cyanoacetic acid and various alcohols with excellent yields (up to 91%) has been demonstrated using 5 mol% Zn3(PO4)2 as a nanocatalyst. Subsequently, using the same nanocatalyst, various substituted electrophilic alkenes and coumarin derivative have been synthesized in good to excellent yields (up to 95%) via Knoevenagel condensation in water as green solvent. The nanocatalyst has been efficiently utilized to synthesize substituted electrophilic alkenes via sequential esterification and Knoevenagel condensation under one-pot green and aqueous conditions. The developed protocol has several advantages including green reaction conditions, operationally simple, high yields and selectivity of products, cost-effectiveness, and nanocatalyst is easily synthesizable, efficient, nontoxic, recoverable and recyclable.

Graphical abstract

An efficient green protocol for the synthesis of cyanoacetic esters, substituted electrophilic alkenes and coumarin derivative have been developed using 5 mol% Zn3(PO4)2 as recoverable and recyclable nanocatalyst. The same nanocatalyst has been efficiently utilized to synthesize substituted electrophilic alkenes via sequential esterification and Knoevenagel condensation under one-pot reaction conditions.