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<p>Amides and <i>α</i>-ketoamides are ubiquitous in drugs and fine chemicals. A recent study by Li and co-workers<sup>1</sup> reported a modular electrolysis-paired tandem strategy that produces both families of compounds in a single electrochemical setup by combining cathodic CO<sub>2</sub>-to-CO conversion with palladium-catalyzed aminocarbonylation and anodic iodine-mediated ketoamidation. The system achieves “two birds with one stone” synthesis. This commentary highlights the significance of this study from an electrochemist’s perspective.</p> Graphical Abstract <p>This highlights the recent work by Qing Li and co-workers (<i>Angew. Chem. Int. Ed.</i> <b>2025</b>, 33, e202503440) on the modular synchronous electrosynthesis of amides and <i>α</i>-ketoamides from a broader perspective.</p>

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A single electrolyzer-making amides and α-ketoamides together: A “sweet fusion” of electrocatalysis and chemocatalysis!

  • 期刊论文

  • 发表日期：

    2025年10月18日

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  • Anantharaj Sengeni

摘要

Amides and α-ketoamides are ubiquitous in drugs and fine chemicals. A recent study by Li and co-workers1 reported a modular electrolysis-paired tandem strategy that produces both families of compounds in a single electrochemical setup by combining cathodic CO2-to-CO conversion with palladium-catalyzed aminocarbonylation and anodic iodine-mediated ketoamidation. The system achieves “two birds with one stone” synthesis. This commentary highlights the significance of this study from an electrochemist’s perspective.

Graphical Abstract

This highlights the recent work by Qing Li and co-workers (Angew. Chem. Int. Ed. 2025, 33, e202503440) on the modular synchronous electrosynthesis of amides and α-ketoamides from a broader perspective.