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<p>An efficient and environmentally benign cyclocondensation of anthranilamide, aldehyde, and Anderson-type hexamolybdochromate (III) is described for the synthesis of 2,3-dihydroquinazolin-4(<i>1H</i>)-ones analog (DHQs) through a one-pot two-component reaction at room temperature. This method offers mild reaction conditions, simple purification without column chromatography, and moderate to good yields for constructing 2-substituted-2,3-dihydroquinazolin-4(<i>1H</i>)-one derivative. Various spectroscopic investigations are used to establish the structures of the target molecules.</p> Graphical abstract <p>The present work reports the environmentally benign synthesis of 2-substituted-2,3-dihydroquinazolin-4(<i>1H</i>)-one analogs (2,3-DHQs) via the cyclocondenzation of 2-aminobenzamide and aldehydes at room temperature in an aqueous medium, using sodium hexamolybdochromate (III) as a catalyst. This methodology is efficient and simple, providing better product yield and reduced reaction time.</p>

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Environmentally benign synthesis of 2,3-dihydroquinazolin-4(1H)-ones by using sodium hexamolybdochromate (III) as a catalyst

  • 期刊论文

  • 发表日期：

    2025年12月2日

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  • Pallavi Kadam,
  • Sandip Sabale,
  • Arjun Kumbhar,
  • Amit Supale

摘要

An efficient and environmentally benign cyclocondensation of anthranilamide, aldehyde, and Anderson-type hexamolybdochromate (III) is described for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones analog (DHQs) through a one-pot two-component reaction at room temperature. This method offers mild reaction conditions, simple purification without column chromatography, and moderate to good yields for constructing 2-substituted-2,3-dihydroquinazolin-4(1H)-one derivative. Various spectroscopic investigations are used to establish the structures of the target molecules.

Graphical abstract

The present work reports the environmentally benign synthesis of 2-substituted-2,3-dihydroquinazolin-4(1H)-one analogs (2,3-DHQs) via the cyclocondenzation of 2-aminobenzamide and aldehydes at room temperature in an aqueous medium, using sodium hexamolybdochromate (III) as a catalyst. This methodology is efficient and simple, providing better product yield and reduced reaction time.