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<p>We developed a mild protocol for the formal insertion of diazo compounds into the C–H bond of electron deficient 1,3-dicarbonyl compounds. The Lewis acid-catalyzed reaction proceeds through protonation of the diazo compound followed by nucleophilic substitution of diazo-N<sub>2</sub> with dicarbonyl substrate. The reaction is notable for its mild conditions, wide substrate scope and high yields of the products.</p> Graphical abstract <p></p>

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Lewis acid-catalyzed diazo insertion into electron-deficient C–H bonds

  • 期刊论文

  • 发表日期：

    2025年4月29日

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  • Jalaj Kumar Pathak,
  • Namrata Rastogi

摘要

We developed a mild protocol for the formal insertion of diazo compounds into the C–H bond of electron deficient 1,3-dicarbonyl compounds. The Lewis acid-catalyzed reaction proceeds through protonation of the diazo compound followed by nucleophilic substitution of diazo-N2 with dicarbonyl substrate. The reaction is notable for its mild conditions, wide substrate scope and high yields of the products.

Graphical abstract