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<p>A rapid and environmentally friendly method was developed for synthesizing 1,5-benzodiazepine derivatives, utilizing catalytic quantities of thiamine hydrochloride in an aqueous media. The desired compounds were acquired with notable yields by amalgamating variously substituted aryl aldehydes with dimedone and o-phenylene diamine using thiamine hydrochloride as a catalyst. This approach presents several benefits, including swift reaction kinetics, utilization of eco-friendly solvents, straightforward workup procedures and a facile purification process, ensuring energy conservation and extensive compatibility with diverse substrates.</p> Graphical Abstract <p><b>Synopsis</b>. A green, rapid, and efficient method for synthesizing 1,5-benzodiazepine derivatives was developed using thiamine hydrochloride as a catalyst in water. This environmentally benign approach achieved excellent yields, compatibility with diverse substrates, and minimal reaction times, highlighting its potential as a sustainable alternative in heterocyclic compound synthesis.</p>

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Thiamine hydrochloride catalyzed environmentally benign synthesis of benzodiazepines in water

  • 期刊论文

  • 发表日期：

    2025年4月29日

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  • Rajesh D Shanbhag,
  • Yatin U Gadkari,
  • Angad B Barkule,
  • Savita B Lomte,
  • Vikas N Telvekar

摘要

A rapid and environmentally friendly method was developed for synthesizing 1,5-benzodiazepine derivatives, utilizing catalytic quantities of thiamine hydrochloride in an aqueous media. The desired compounds were acquired with notable yields by amalgamating variously substituted aryl aldehydes with dimedone and o-phenylene diamine using thiamine hydrochloride as a catalyst. This approach presents several benefits, including swift reaction kinetics, utilization of eco-friendly solvents, straightforward workup procedures and a facile purification process, ensuring energy conservation and extensive compatibility with diverse substrates.

Graphical Abstract

Synopsis. A green, rapid, and efficient method for synthesizing 1,5-benzodiazepine derivatives was developed using thiamine hydrochloride as a catalyst in water. This environmentally benign approach achieved excellent yields, compatibility with diverse substrates, and minimal reaction times, highlighting its potential as a sustainable alternative in heterocyclic compound synthesis.