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<p>Use of magnesium oxide-coated magnetite nanoparticles (Fe<sub>3</sub>O<sub>4</sub>@MgO) as a heterogeneous base-catalyst in organic functional group transformations has been demonstrated. Catalytic efficiency of the Fe<sub>3</sub>O<sub>4</sub>@MgO platform as an inorganic base-catalyst was firstly explored in the oxidative hydroxylation of arylboronic acids in the presence of aq. H<sub>2</sub>O<sub>2</sub>, affording the corresponding phenols with outstanding effectiveness. In addition, the direct <i>O</i>-benzylation of phenols catalyszed by the Fe<sub>3</sub>O<sub>4</sub>@MgO platform, was efficiently conducted in an aqueous environment, resulting in the formation of benzyl phenyl ethers. Lastly, the hydration of benzonitriles was also achieved when the Fe<sub>3</sub>O<sub>4</sub>@MgO platform was employed under aqueous conditions, yielding the corresponding benzamides.</p> Graphic abstract <p>Magnesium oxide-coated magnetite nanoparticles (Fe O @MgO) were used as a base catalyst in organic transformations. It efficiently catalyzed the oxidative hydroxylation of arylboronic acids, O-benzylation of phenols, and hydration of benzonitriles in aqueous conditions, producing phenols, benzyl phenyl ethers, and benzamides, respectively.</p> <p></p>

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Utilization of Fe3O4@MgO as a heterogeneous solid-base in functional group transformations of arylboronic acids, phenols and benzonitriles

  • 期刊论文

  • 发表日期：

    2025年1月9日

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  • Cho-Yeon Kim,
  • Chae-Ri Lim,
  • Seung-Hoi Kim

摘要

Use of magnesium oxide-coated magnetite nanoparticles (Fe3O4@MgO) as a heterogeneous base-catalyst in organic functional group transformations has been demonstrated. Catalytic efficiency of the Fe3O4@MgO platform as an inorganic base-catalyst was firstly explored in the oxidative hydroxylation of arylboronic acids in the presence of aq. H2O2, affording the corresponding phenols with outstanding effectiveness. In addition, the direct O-benzylation of phenols catalyszed by the Fe3O4@MgO platform, was efficiently conducted in an aqueous environment, resulting in the formation of benzyl phenyl ethers. Lastly, the hydration of benzonitriles was also achieved when the Fe3O4@MgO platform was employed under aqueous conditions, yielding the corresponding benzamides.

Graphic abstract

Magnesium oxide-coated magnetite nanoparticles (Fe O @MgO) were used as a base catalyst in organic transformations. It efficiently catalyzed the oxidative hydroxylation of arylboronic acids, O-benzylation of phenols, and hydration of benzonitriles in aqueous conditions, producing phenols, benzyl phenyl ethers, and benzamides, respectively.