An efficient and environmental friendly synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione in aqueous hydrotropic medium
摘要
This study reports a hydrotropic activity for synthesizing 1H-pyrazolo[1,2-b]phthalazine-5,10-dione through one pot four component aldehyde condensation, malononitrile, phthalic anhydride, and hydrazine hydrate. The simple and green hydrotropic synthetic approach offers numerous advantages such as non-toxic, inexpensive, mild reaction conditions, avoidance of harmful solvents, shorter reaction time, an excellent yield of products, simple workup, Chromatography-free, and eco-friendly. 1H-NMR confirmed all the synthesized compounds.
Graphical abstract