Efficient one-pot synthesis of 3-arylmethyl indoles promoted by (Bu3Sn)2MoO4 as a reusable catalyst
摘要
An efficient multi-component protocol for synthesizing substituted 3-arylmethyl indoles derivatives through a three-component strategy using water: ethanol (H2O:EtOH) at 45–50°C with good to excellent yields. The main advantages of this protocol are mild reaction conditions, easy workup, and recyclability of the catalyst for up to four catalytic cycles.
Graphical abstractSynopsis: Synthesis of substituted 3-arylmethyl indoles by using efficient multi-component strategy in ethanol: water as a solvent system by using (Bu3Sn)2MoO4 as a reusable catalyst at 45–50 °C with good to excellent yields. The catalyst is reusable in four catalytic cycles.