Efficient one-pot process for synthesis of antiviral drug amantadine hydrochloride

期刊论文
发表日期：

2024年5月15日

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Vilas Sudrik,
Dnyaneshwar Karpe,
Manohar Suryawanshi,
Dattatraya Ukale,
Arjun Bodkhe,
Shamrao Lawande

摘要

The synthesis of amantadine hydrochloride from 1-bromoadamantane utilizing urea and methanol is described as a one-pot, efficient, and sustainable process by optimizing reaction conditions. This method employs a phase transfer catalyst, TBAI, and in situ salt formation with HCl, resulting in the desired product with enhanced yield and purity.

Graphical Abstract

The synthesis of amantadine hydrochloride from 1-bromoadamantane utilizing urea and methanol is described as a one-pot, efficient, and sustainable process through the optimization of reaction conditions. This method employs a phase transfer catalyst, TBAI, and in situ salt formation with HCl, resulting in the desired product with enhanced yield and purity.