A novel water-soluble quinoxalino[2,3-a] phenazine-based organic NIR photothermal agent for cancer phototherapy application

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发表日期：

2024年5月9日

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Siqi Liu,
Xu Zhao,
Hongying Ding,
Liuyi Yang,
Meng Zhao,
Gaolei Xi,
Tao Jia

摘要

Organic near-infrared (NIR) photothermal agents have tremendous potential in cancer therapy. Herein we report anovel NIR light responsive photothermal agent DDHT/F127 micelles, which has excellent photothermal properties and photostability, along with outstanding outcomes in cancer phototherapy.

Graphical abstract

A novel donor-acceptor (D-A)-type organic photothermal material 5,18-dibutyl-5,18- dihydro-diquinoxaline[2,3-a:2',3'-c]-phenazine (DDHT) was encapsulated with Pluronic^® 127 (F127) material to form NIR light responsive photothermal agent DDHT/F127 micelles, which has excellent photothermal properties with photothermal conversion efficiency of 51.55% under 655 nm NIR laser irradiation, along with outstanding outcomes in cancer therapy.