KOH-catalyzed cross-coupling of primary and secondary alcohols: evidence for radical pathways
摘要
A simple base, KOH-catalyzed cross-coupling of primary and secondary alcohols is reported in which the primary alcohols play the role of alkylation reagents. EPR and mechanistic studies confirmed the involvement of radical and ketone intermediates formed from primary and secondary alcohols, respectively, leading to the formation of β-alkylated secondary alcohols.
Graphical abstractA simple base-catalyzed synthesis of higher secondary alcohols directly from the cross-coupling of primary and secondary alcohols is reported.