Scholarlink

<p>Marine fungi are the leading producers of bioactive metabolites with medicinal properties against several diseases. However, since marine species survive in diverse climates, they are usually difficult to culture in laboratory set-ups, making them challenging to study. This study aimed to optimize culture conditions for marine fungi and evaluate the inhibitory action of the marine extract on primary pro-inflammatory cytokines. Culture conditions for marine fungi were optimized using biomass production, hyphal density, and radial extension, considering temperature and humidity. The study isolated a new <i>Aspergillus fumigatus</i> variant, AFK11 (GenBank accession no. JX022941), showing 96% similarity to reported strains. Ethyl acetate extracts of AFK11 significantly inhibited primary pro-inflammatory cytokines, tumor necrosis factor-α, and interleukin-6, in a dose-dependent manner. This research highlights the successful laboratory culture and anti-inflammatory potential of the new strain of <i>Aspergillus</i>, AFK11, emphasizing the need for further research for its potential in various other diseases such as cancer.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Isolation of a novel marine Aspergillus fumigatus strain AFK11 and inhibition of inflammatory mediators

  • 期刊论文

  • 发表日期：

    2025年5月5日

查看全文
  • Kranti Kiran Reddy Ealla,
  • Neema Kumari,
  • Se-Kwon Kim,
  • Nimisha Rawat,
  • Anuradha Mokkapati,
  • Ira Bhatnagar

摘要

Marine fungi are the leading producers of bioactive metabolites with medicinal properties against several diseases. However, since marine species survive in diverse climates, they are usually difficult to culture in laboratory set-ups, making them challenging to study. This study aimed to optimize culture conditions for marine fungi and evaluate the inhibitory action of the marine extract on primary pro-inflammatory cytokines. Culture conditions for marine fungi were optimized using biomass production, hyphal density, and radial extension, considering temperature and humidity. The study isolated a new Aspergillus fumigatus variant, AFK11 (GenBank accession no. JX022941), showing 96% similarity to reported strains. Ethyl acetate extracts of AFK11 significantly inhibited primary pro-inflammatory cytokines, tumor necrosis factor-α, and interleukin-6, in a dose-dependent manner. This research highlights the successful laboratory culture and anti-inflammatory potential of the new strain of Aspergillus, AFK11, emphasizing the need for further research for its potential in various other diseases such as cancer.

Graphical Abstract