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<p>The current management of neurological disorders remains largely symptomatic. In recent years, stem cell–derived exosomes have emerged as a promising alternative therapeutic strategy. This narrative review synthesizes evidence from preclinical studies investigating the mechanisms and efficacy of exosome-based therapy for neurological conditions. The included studies encompass animal models and in vitro systems. Accumulating preclinical evidence consistently supports the therapeutic potential of stem cell–derived exosomes across several neurological disorders. In Alzheimer’s disease models, stem cell–derived exosomes reduce β-amyloid plaque deposition and attenuate neuroinflammation. For Parkinson’s disease, they exert neuroprotective effects on dopaminergic neurons. They also inhibit α-synuclein aggregation. In ischemic stroke and spinal cord injury, stem cell–derived exosomes promote functional recovery through multiple mechanisms. These include suppressing ferroptosis, promoting angiogenesis, and stimulating axonal regeneration. Improved delivery strategies, such as intranasal administration and hydrogel encapsulation, have further enhanced brain targeting and treatment durability. Despite these promising preclinical findings, several challenges remain. A primary issue is the lack of standardized preparation protocols. Significant uncertainties also exist regarding long-term safety. Furthermore, pathways for clinical translation are still unclear. Future research should prioritize elucidating the underlying mechanisms of exosome therapy. The refinement of targeted delivery systems is equally important. Finally, advancing rigorously designed clinical trials is crucial to facilitate the translation of these therapies into clinical practice.</p>

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Therapeutic Mechanisms of Stem Cell–Derived Exosomes for Neurological Disorders: An Overview

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • Congying Lin,
  • Lixin Qi,
  • Xiuying Gao,
  • Lei Hu,
  • Bo Qian,
  • Yixuan Deng,
  • Chunting Zhou,
  • Chenyi Wang,
  • Guanhao Liu,
  • Qiang Ding,
  • Zhenlang Lin,
  • Xuwei Zhu,
  • Min Zhang

摘要

The current management of neurological disorders remains largely symptomatic. In recent years, stem cell–derived exosomes have emerged as a promising alternative therapeutic strategy. This narrative review synthesizes evidence from preclinical studies investigating the mechanisms and efficacy of exosome-based therapy for neurological conditions. The included studies encompass animal models and in vitro systems. Accumulating preclinical evidence consistently supports the therapeutic potential of stem cell–derived exosomes across several neurological disorders. In Alzheimer’s disease models, stem cell–derived exosomes reduce β-amyloid plaque deposition and attenuate neuroinflammation. For Parkinson’s disease, they exert neuroprotective effects on dopaminergic neurons. They also inhibit α-synuclein aggregation. In ischemic stroke and spinal cord injury, stem cell–derived exosomes promote functional recovery through multiple mechanisms. These include suppressing ferroptosis, promoting angiogenesis, and stimulating axonal regeneration. Improved delivery strategies, such as intranasal administration and hydrogel encapsulation, have further enhanced brain targeting and treatment durability. Despite these promising preclinical findings, several challenges remain. A primary issue is the lack of standardized preparation protocols. Significant uncertainties also exist regarding long-term safety. Furthermore, pathways for clinical translation are still unclear. Future research should prioritize elucidating the underlying mechanisms of exosome therapy. The refinement of targeted delivery systems is equally important. Finally, advancing rigorously designed clinical trials is crucial to facilitate the translation of these therapies into clinical practice.