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<p>The first 30&#xa0;days postnatal represent a critical window for brain development in mammals. During this period, the gamma-aminobutyric acid (GABA) receptor undergoes significant functional and structural changes that are pivotal for neuronal maturation, synaptogenesis, and network stabilization. This article provides a comprehensive overview on the postnatal development of GABA receptors, highlighting their roles in inhibitory neurotransmission, developmental plasticity, and the transition from excitatory to inhibitory signaling. We also discuss the implications of dysregulated GABAergic signaling in neurodevelopmental disorders and the potential for therapeutic interventions.</p>

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The First 30 Days Postnatal of the GABA Receptor: A Comprehensive Overview

  • 期刊论文

  • 发表日期：

    2025年11月17日

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  • Raffaele Falsaperla,
  • Ausilia Desiree Collotta,
  • Vincenzo Sortino,
  • Cristina Malaventura,
  • Michela Spatuzza,
  • Catia Romano,
  • Agnese Suppiej

摘要

The first 30 days postnatal represent a critical window for brain development in mammals. During this period, the gamma-aminobutyric acid (GABA) receptor undergoes significant functional and structural changes that are pivotal for neuronal maturation, synaptogenesis, and network stabilization. This article provides a comprehensive overview on the postnatal development of GABA receptors, highlighting their roles in inhibitory neurotransmission, developmental plasticity, and the transition from excitatory to inhibitory signaling. We also discuss the implications of dysregulated GABAergic signaling in neurodevelopmental disorders and the potential for therapeutic interventions.