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Background <p>Cervical spondylotic radiculopathy (CSR) is increasingly prevalent, causing neck pain and radiating symptoms. As alternatives to surgery, acupressure stimulation of Jing-jiaji acupoints therapies have gained traction albeit lacking evidence.</p> Methods <p>Rats underwent spinal cord compression modeling CSR or sham surgery, alongside normal controls. A week post-surgery, CSR rats underwent no intervention or standardized acupressure of Jing-jiaji acupoints at 2, 4 or 6N. Sensory, locomotor and electrophysiological functions were assessed along with tissue analyses for pain mediators.</p> Results <p>Relative to sham group, untreated CSR rats exhibited mechanical/pressure pain hypersensitivity, gait impairments, slowed nerve conduction velocities and reduced sensory evoked potentials, accompanied by heightened spinal inflammation and neuronal damage. Acupressure markedly attenuated these neuropathic CSR manifestations in a stimulus-dependent manner, with maximal therapeutic efficacy observed at 4-6N intensity.</p> Conclusion <p>This study demonstrates bilateral acupressure stimulation of neck Jing-jiaji acupoints to effectively mitigate characteristic neurogenic pain and neurological dysfunction in a rodent CSR model.</p>

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Analgesic Effects of Acupressure on Jing-jiaji Acupoints in a Rat Model of Cervical Spondylotic Radiculopathy

  • 期刊论文

  • 发表日期：

    2025年5月17日

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  • Shang-Hong Jiang,
  • Song Yang,
  • Ling Meng,
  • Ling-Yao Xie,
  • Jia-Ni Yang,
  • Si-Qi Li,
  • Ke-Ying Liao,
  • Zhi-Fang Qiu,
  • Yao-Yao Xiao,
  • Man-Di Fu,
  • Zhi-Li Liu,
  • Xue-Yu Jiang

摘要

Background

Cervical spondylotic radiculopathy (CSR) is increasingly prevalent, causing neck pain and radiating symptoms. As alternatives to surgery, acupressure stimulation of Jing-jiaji acupoints therapies have gained traction albeit lacking evidence.

Methods

Rats underwent spinal cord compression modeling CSR or sham surgery, alongside normal controls. A week post-surgery, CSR rats underwent no intervention or standardized acupressure of Jing-jiaji acupoints at 2, 4 or 6N. Sensory, locomotor and electrophysiological functions were assessed along with tissue analyses for pain mediators.

Results

Relative to sham group, untreated CSR rats exhibited mechanical/pressure pain hypersensitivity, gait impairments, slowed nerve conduction velocities and reduced sensory evoked potentials, accompanied by heightened spinal inflammation and neuronal damage. Acupressure markedly attenuated these neuropathic CSR manifestations in a stimulus-dependent manner, with maximal therapeutic efficacy observed at 4-6N intensity.

Conclusion

This study demonstrates bilateral acupressure stimulation of neck Jing-jiaji acupoints to effectively mitigate characteristic neurogenic pain and neurological dysfunction in a rodent CSR model.