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<p>The unique properties of silk, a natural protein-based biopolymer, including its high mechanical strength, chemical modifiability, biocompatibility, and biodegradability, have drawn interest in drug delivery science. Fibroin and sericin are the proteins that mainly comprise silk, which is derived chiefly from the <i>Bombyx mori</i> silkworm and certain spider species. The <i>β</i>-sheet crystallites in the silk-fibroin structure enhance the material properties, such as high strength and extensibility. Numerous drug delivery systems have been produced using silk, such as fibers, hydrogels, microparticles, nanoparticles, and liposomes. These systems have a wide range of applications, including parenteral, oral, transdermal, ocular, pulmonary, and local bone implantation. In this study, the origins, extraction methods, chemical structure, physicochemical properties, sterilization methods, and applications in drug delivery systems of silk are extensively discussed. Additionally, current studies in the literature were compiled and evaluated. While current studies are promising for the future, further comprehensive research is necessary to integrate silk-based drug delivery systems into clinical applications.</p>

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Silk-based drug delivery systems: Advances, challenges, and future perspectives

  • 期刊论文

  • 发表日期：

    2026年4月29日

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  • Heybet Kerem Polat,
  • Yasin Turanlı,
  • Emre Tuncel,
  • Nihat Kurt

摘要

The unique properties of silk, a natural protein-based biopolymer, including its high mechanical strength, chemical modifiability, biocompatibility, and biodegradability, have drawn interest in drug delivery science. Fibroin and sericin are the proteins that mainly comprise silk, which is derived chiefly from the Bombyx mori silkworm and certain spider species. The β-sheet crystallites in the silk-fibroin structure enhance the material properties, such as high strength and extensibility. Numerous drug delivery systems have been produced using silk, such as fibers, hydrogels, microparticles, nanoparticles, and liposomes. These systems have a wide range of applications, including parenteral, oral, transdermal, ocular, pulmonary, and local bone implantation. In this study, the origins, extraction methods, chemical structure, physicochemical properties, sterilization methods, and applications in drug delivery systems of silk are extensively discussed. Additionally, current studies in the literature were compiled and evaluated. While current studies are promising for the future, further comprehensive research is necessary to integrate silk-based drug delivery systems into clinical applications.