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<p>Vascular intimal hyperplasia, primarily driven by the abnormal proliferation of vascular smooth muscle cells (VSMCs), is a major contributor to restenosis. Therefore, the development of efficient drug delivery systems capable of inhibiting VSMC proliferation is of great clinical significance. In this study, a novel multifunctional nanohybrid, 1-DASA-ATPMS@CP1@Curcumin, was successfully synthesized for the delivery and electrochemical sensing of curcumin. The electrochemical behavior of the composite was systematically investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Key parameters, including accumulation time, pH, scan rate, surfactant type, and electrochemical mechanism, were optimized. The composite exhibited excellent electrochemical response in pH 7.0 phosphate-buffered saline (PBS) containing 10.0 μg mL<sup>−1</sup> CTAB, with a wide linear detection range of 0.5–100.0 μM for curcumin and a low detection limit of 0.05 μM. <i>In vitro</i> studies using CCK-8 assays showed that 1-DASA-ATPMS@CP1@Curcumin significantly suppressed the proliferation of human aortic smooth muscle cells (HASMCs), outperforming both free curcumin and blank carrier groups. These findings highlight the potential of this nanohybrid as an effective therapeutic platform for the prevention of vascular intimal hyperplasia.</p>

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Electrochemical detection of curcumin using nanohybrid material for the prevention of vascular intimal hyperplasia

  • 期刊论文

  • 发表日期：

    2026年4月20日

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  • Mingdi Zhu,
  • Yunfei Zhang,
  • Linlin Zhang

摘要

Vascular intimal hyperplasia, primarily driven by the abnormal proliferation of vascular smooth muscle cells (VSMCs), is a major contributor to restenosis. Therefore, the development of efficient drug delivery systems capable of inhibiting VSMC proliferation is of great clinical significance. In this study, a novel multifunctional nanohybrid, 1-DASA-ATPMS@CP1@Curcumin, was successfully synthesized for the delivery and electrochemical sensing of curcumin. The electrochemical behavior of the composite was systematically investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Key parameters, including accumulation time, pH, scan rate, surfactant type, and electrochemical mechanism, were optimized. The composite exhibited excellent electrochemical response in pH 7.0 phosphate-buffered saline (PBS) containing 10.0 μg mL−1 CTAB, with a wide linear detection range of 0.5–100.0 μM for curcumin and a low detection limit of 0.05 μM. In vitro studies using CCK-8 assays showed that 1-DASA-ATPMS@CP1@Curcumin significantly suppressed the proliferation of human aortic smooth muscle cells (HASMCs), outperforming both free curcumin and blank carrier groups. These findings highlight the potential of this nanohybrid as an effective therapeutic platform for the prevention of vascular intimal hyperplasia.