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<p>MicroRNAs (miRNAs) and epigenetic processes in bovine adipocytes can provide valuable new insights into controlling adipogenesis in livestock. It modulates gene expression at the posttranscriptional stage by affecting mRNA translation and stability. It plays a significant role in the regulation of a wide range of physiological and cellular functions, such as immune system processes and cellular and intramuscular fat development. Transcriptional regulators such as PPARγ and C/EBP proteins are key mediators of the critical processes governing progenitor cell differentiation into adipocytes. The differentiation of these progenitor cells into adipocytes, as well as the subsequent lipid deposition within the adipocytes, is influenced by a variety of factors. These include genetics; epigenetics; nutritional; hormonal regulation; weaning and slaughtering; aging and weight; and stress levels. Epigenetic modifications such as chromatin reorganization, histone alterations, and DNA methylation subsequently affect the activation of genes related to adipogenesis and the progression of adipocyte differentiation. By investigating how fat deposition is epigenetically regulated in beef cattle, scientists aim to unravel molecular mechanisms, identify key regulatory genes and pathways, and develop targeted strategies for modifying fat deposition to enhance desirable traits such as marbling and meat tenderness. This review paper delves into miRNAs and epigenetic factors and their role in regulating bovine adipocytes and it will identify links to transcription factors that influence diverse aspects of meat quality, encompassing flavor, juiciness, tenderness, firmness, texture, and visual appearance. Cutting-edge developments in genomics, including the identification of molecular markers and genetic variations, hold promise for enhancing animal productivity and meeting the global demand for premium-quality meat. This review establishes a foundation for future research on understanding regulatory networks linked to miRNAs and epigenetic changes, contributing to both scholarly knowledge advancement and practical applications within animal agriculture.</p>

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Molecular Genetics and Epigenetics Regulatory Role of miRNAs on Adipogenesis and Intramuscular Fat Development in Beef Cattle: In the Context of Meat Quality

  • 期刊论文

  • 发表日期：

    2025年11月3日

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  • Diba Dedacha Jilo,
  • Belete Kuraz Abebe,
  • Jianfang Wang,
  • Juntao Guo,
  • Haibing Liu,
  • Qiu Liang,
  • Anning Li,
  • Linsen Zan

摘要

MicroRNAs (miRNAs) and epigenetic processes in bovine adipocytes can provide valuable new insights into controlling adipogenesis in livestock. It modulates gene expression at the posttranscriptional stage by affecting mRNA translation and stability. It plays a significant role in the regulation of a wide range of physiological and cellular functions, such as immune system processes and cellular and intramuscular fat development. Transcriptional regulators such as PPARγ and C/EBP proteins are key mediators of the critical processes governing progenitor cell differentiation into adipocytes. The differentiation of these progenitor cells into adipocytes, as well as the subsequent lipid deposition within the adipocytes, is influenced by a variety of factors. These include genetics; epigenetics; nutritional; hormonal regulation; weaning and slaughtering; aging and weight; and stress levels. Epigenetic modifications such as chromatin reorganization, histone alterations, and DNA methylation subsequently affect the activation of genes related to adipogenesis and the progression of adipocyte differentiation. By investigating how fat deposition is epigenetically regulated in beef cattle, scientists aim to unravel molecular mechanisms, identify key regulatory genes and pathways, and develop targeted strategies for modifying fat deposition to enhance desirable traits such as marbling and meat tenderness. This review paper delves into miRNAs and epigenetic factors and their role in regulating bovine adipocytes and it will identify links to transcription factors that influence diverse aspects of meat quality, encompassing flavor, juiciness, tenderness, firmness, texture, and visual appearance. Cutting-edge developments in genomics, including the identification of molecular markers and genetic variations, hold promise for enhancing animal productivity and meeting the global demand for premium-quality meat. This review establishes a foundation for future research on understanding regulatory networks linked to miRNAs and epigenetic changes, contributing to both scholarly knowledge advancement and practical applications within animal agriculture.