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<p>Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) gene is a member of aldehyde dehydrogenase (ALDH) family, and it is closely associated with cancer metastasis. However, the exact mechanism remains to be clarified. In the present study, we aimed to explore the specific mechanism and role of ALDH1A1 in colorectal cancer (CRC) metastasis. The data obtained from GSE41657 dataset and 24 surgical resected CRC samples was analyzed to explore the expression of ALDH1A1 in CRC and its clinical importance. ALDH1Al expression was increased in CRC tissues and correlated to poor prognosis. ALDH1A1 was highly expressed in CRC cells and ALDH1Al knocking down led to reduced proliferation, migration, and invasion of CRC cells. In terms of the mechanisms, ALDH1Al knockdown or inhibiter caused the significantly reduced gene expression of Notch1, JAG1, and HES1. ALDH1A1 activates Notch signaling pathway to promote CRC growth and development. Our study demonstrated that ALDH1Al could promote CRC cell proliferation, migration, and invasion via activating the Notch signaling pathway. Targeting ALDH1Al might be promising for inhibition of CRC metastasis.</p>

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ALDH1A1 promotes colorectal cancer metastasis through activating the notch signaling pathway

  • 期刊论文

  • 发表日期：

    2025年8月4日

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  • Xiaoran Wang,
  • Xiaoduo Wen,
  • Xvhua Hu,
  • Wenbo Niu,
  • Ganlin Guo,
  • Fei Yang,
  • Bin Yu,
  • Sujun Fan

摘要

Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) gene is a member of aldehyde dehydrogenase (ALDH) family, and it is closely associated with cancer metastasis. However, the exact mechanism remains to be clarified. In the present study, we aimed to explore the specific mechanism and role of ALDH1A1 in colorectal cancer (CRC) metastasis. The data obtained from GSE41657 dataset and 24 surgical resected CRC samples was analyzed to explore the expression of ALDH1A1 in CRC and its clinical importance. ALDH1Al expression was increased in CRC tissues and correlated to poor prognosis. ALDH1A1 was highly expressed in CRC cells and ALDH1Al knocking down led to reduced proliferation, migration, and invasion of CRC cells. In terms of the mechanisms, ALDH1Al knockdown or inhibiter caused the significantly reduced gene expression of Notch1, JAG1, and HES1. ALDH1A1 activates Notch signaling pathway to promote CRC growth and development. Our study demonstrated that ALDH1Al could promote CRC cell proliferation, migration, and invasion via activating the Notch signaling pathway. Targeting ALDH1Al might be promising for inhibition of CRC metastasis.