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<p>The significance of cancer treatment research lies in addressing the high incidence of cancer, overcoming treatment challenges, and mitigating the harsh side effects of chemotherapeutic agents. Currently, nanotechnology is garnering significant attention for its potential applications in diagnostics and drug delivery, offering innovative solutions for disease detection and treatment. Among different types of nanoparticles (NPs), polymeric nanoparticles comprise&#xa0;biocompatible and biodegradable polymers that&#xa0;enhance drug pharmacokinetics and pharmacodynamics, minimize adverse effects, increase stability, and facilitate sustained drug release. These polymeric nanoparticle-based nanomedicines offer a versatile platform for various cancer treatments, notably enabling targeted drug delivery directly to tumors, tumor-imaging, hyperthermia, and photodynamic therapy. Being polymeric in nature polydopamine (PDA) nanomaterials are appeared as promising approaches in biology and medicine. This review article offers a concise summary of the latest developments in polydopamine-based cancer treatment, covering key findings, limitations, and emerging trend therapeutic approach of polydopamine nanomaterials, along with the properties and various methods of preparation. Physico-chemical properties of PDA-based nanomaterials in therapeutics have permitted several successful modifications in the field of cancer treatment.</p> Graphical abstract <p>Schematic illustration of the synthesis and application of different types of polydopamine-based nanomaterials by polymerizing the dopamine monomer under a&#xa0;basic environment. Polydopamine nanomaterials are being developed as prospective tools in different cancer therapies as well as cancer diagnosis and detection through the modification of other nanoparticles or by direct binding to chemotherapeutic agents. Different tumor-specific target modifications of polydopamine nanoparticles have been&#xa0;developed for active drug delivery to&#xa0;cancer cells.</p> <p></p>

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A review on the advancement of polydopamine (PDA)-based nanomaterials for cancer treatment

  • 期刊论文

  • 发表日期：

    2025年4月16日

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  • Rumi Mahata,
  • Sounik Manna,
  • Mrinmoyee Modak,
  • Sujata Maiti Choudhury

摘要

The significance of cancer treatment research lies in addressing the high incidence of cancer, overcoming treatment challenges, and mitigating the harsh side effects of chemotherapeutic agents. Currently, nanotechnology is garnering significant attention for its potential applications in diagnostics and drug delivery, offering innovative solutions for disease detection and treatment. Among different types of nanoparticles (NPs), polymeric nanoparticles comprise biocompatible and biodegradable polymers that enhance drug pharmacokinetics and pharmacodynamics, minimize adverse effects, increase stability, and facilitate sustained drug release. These polymeric nanoparticle-based nanomedicines offer a versatile platform for various cancer treatments, notably enabling targeted drug delivery directly to tumors, tumor-imaging, hyperthermia, and photodynamic therapy. Being polymeric in nature polydopamine (PDA) nanomaterials are appeared as promising approaches in biology and medicine. This review article offers a concise summary of the latest developments in polydopamine-based cancer treatment, covering key findings, limitations, and emerging trend therapeutic approach of polydopamine nanomaterials, along with the properties and various methods of preparation. Physico-chemical properties of PDA-based nanomaterials in therapeutics have permitted several successful modifications in the field of cancer treatment.

Graphical abstract

Schematic illustration of the synthesis and application of different types of polydopamine-based nanomaterials by polymerizing the dopamine monomer under a basic environment. Polydopamine nanomaterials are being developed as prospective tools in different cancer therapies as well as cancer diagnosis and detection through the modification of other nanoparticles or by direct binding to chemotherapeutic agents. Different tumor-specific target modifications of polydopamine nanoparticles have been developed for active drug delivery to cancer cells.