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Background and Aims <p>Currently, there are no biomarkers with high accuracy in the detection of pancreatic cancer. This article aims to evaluate the performance of a novel diagnostic model based on a combination of biomarkers in the washing fluid obtained by EUS-FNA with imaging examination in pancreatic cancer.</p> Methods <p>This study included 59 patients with pancreatic lesions who underwent EUS-FNA and were categorized into malignant and benign groups on the basis of pathology diagnosis. The levels of CEA, CA19-9, CA125, CA724, CYFRA 21–1, IMP3, SMAD4, and S100P in EUS-FNA washing fluid were detected by ELISA. We attempted to construct a new diagnostic method by combining the above biomarkers with EUS, CT, MRI, and PET-CT.</p> Results <p>CEA, CA19-9, CA724, CA125, and CYFRA 21–1 showed statistical significance in the diagnosis of pancreatic cancer (AUC &gt; 0.7, <i>p</i> &lt; 0.05). CA724 had a specificity of up to 100% in the group with positive EUS diagnosis. If at least two positive imaging results (EUS/CT/MRI/PET-CT) combined with at least one tumor marker (CEA/CA199/CA724) in series, the sensitivity was 88.57% and the specificity was 91.67%.</p> Conclusions <p>Combining the tumor markers CEA, CA19-9, CA724, CA125, and CYFRA 21–1 in the washing fluid of EUS-FNA with commonly used imaging methods can help distinguish benign and malignant pancreatic lesions.</p>

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A Novel Diagnostic Model of Biomarkers in the Washing Fluid Obtained by EUS-FNA in Pancreatic Cancer

  • 期刊论文

  • 发表日期：

    2025年3月27日

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  • Chen-Fan Li,
  • Lan-Xiang Hao,
  • Yi-Jia Chen,
  • En-De Lin,
  • Chun-Ping Zhang,
  • Li-Hua Wu,
  • Xu-Ying Liao,
  • Jia-Li Zhou,
  • Jian-Hui Zhu,
  • Ling-Hui Zhan,
  • Xian-Ming Liang,
  • Yi-Qun Hu

摘要

Background and Aims

Currently, there are no biomarkers with high accuracy in the detection of pancreatic cancer. This article aims to evaluate the performance of a novel diagnostic model based on a combination of biomarkers in the washing fluid obtained by EUS-FNA with imaging examination in pancreatic cancer.

Methods

This study included 59 patients with pancreatic lesions who underwent EUS-FNA and were categorized into malignant and benign groups on the basis of pathology diagnosis. The levels of CEA, CA19-9, CA125, CA724, CYFRA 21–1, IMP3, SMAD4, and S100P in EUS-FNA washing fluid were detected by ELISA. We attempted to construct a new diagnostic method by combining the above biomarkers with EUS, CT, MRI, and PET-CT.

Results

CEA, CA19-9, CA724, CA125, and CYFRA 21–1 showed statistical significance in the diagnosis of pancreatic cancer (AUC > 0.7, p < 0.05). CA724 had a specificity of up to 100% in the group with positive EUS diagnosis. If at least two positive imaging results (EUS/CT/MRI/PET-CT) combined with at least one tumor marker (CEA/CA199/CA724) in series, the sensitivity was 88.57% and the specificity was 91.67%.

Conclusions

Combining the tumor markers CEA, CA19-9, CA724, CA125, and CYFRA 21–1 in the washing fluid of EUS-FNA with commonly used imaging methods can help distinguish benign and malignant pancreatic lesions.