Purpose <p>Locally advanced carcinoma colon may need en-bloc resection with microscopic negative margin.</p> Methods <p>We report our novel technique of internal iliac artery transposition to reconstruct the external iliac artery in a case of locally advanced colonic cancer involving the external iliac artery. In this case, adenocarcinoma of the right colon was seen involving the lower pole of the right kidney, right psoas muscle, right ureter and rt sided external iliac vessels.</p> Results <p>Right hemicolectomy was done with right nephrectomy along with resection of the right external iliac artery. The right internal iliac artery was used for the reconstruction of the right external iliac artery.</p> Conclusion <p>Internal iliac artery used as a replacement for excised external iliac artery seems to be a valid alternative to synthetic grafts and femoral-femoral bypass.</p>