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<p>Embalming (EM) reduces residual SARS-CoV-2 in tissues, but its effectiveness on the external body surfaces of corpses infected with coronavirus disease 2019(COVID-19) remains unclear. We therefore examined the presence of SARS-CoV-2 in the pharynx, anus, and on external body surfaces following EM in nine COVID-19-infected corpses, including four full autopsy cases and five minimally invasive autopsy (MIA) cases. Antigen testing and viral quantification using real-time PCR were performed. Nasopharyngeal antigen tests were positive prior to EM and negative thereafter in all nine cases. Among the four autopsy cases, SARS-CoV-2 RNA was detected in all nasopharyngeal samples (100%), in two oropharyngeal samples (50%), and at seven sites (41%) across 17 external body surfaces, three or more days after EM. No viral RNA was detected in anal samples. Among the five MIA cases, viral RNA was detected in two nasopharyngeal samples (40%), one oropharyngeal sample (20%), and at four sites (44%) across nine external body surfaces, three or more days after EM. The reduction in viral load before and after EM exceeded 99%in nasopharynx and oropharyngeal samples in both autopsy and MIA cases, and exceeded 94% on external body surfaces in MIA cases. Moreover, viral reduction was greater several days after EM than immediately following the procedure. These findings suggest that the combination of MIA and EM effectively reduces the detectableSARS-CoV-2 RNA in COVID-19-infected corpses. Additionally, maintaining the body for several days after EM appears to reduce the viral levels.</p>

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Assessing the effectiveness of embalming in cadavers with COVID-19 after full autopsy and minimally invasive autopsy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月10日

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  • Hisako Saitoh,
  • Sayaka Nagasawa,
  • Aika Mori,
  • Yuichiro Hirata,
  • Harutaka Katano,
  • Kazuho Ushiwata,
  • Suguru Torimitsu,
  • Makoto Nakajima,
  • Shigeki Tsuneya,
  • Susumu Kobayashi,
  • Isao Yamamoto,
  • Kimiko Nakagawa,
  • Iwao Hasegawa,
  • Shinji Akitomi,
  • Koichi Sakurada,
  • Tadaki Suzuki,
  • Hirotaro Iwase,
  • Kenichiro Hashizume,
  • Yohsuke Makino

摘要

Embalming (EM) reduces residual SARS-CoV-2 in tissues, but its effectiveness on the external body surfaces of corpses infected with coronavirus disease 2019(COVID-19) remains unclear. We therefore examined the presence of SARS-CoV-2 in the pharynx, anus, and on external body surfaces following EM in nine COVID-19-infected corpses, including four full autopsy cases and five minimally invasive autopsy (MIA) cases. Antigen testing and viral quantification using real-time PCR were performed. Nasopharyngeal antigen tests were positive prior to EM and negative thereafter in all nine cases. Among the four autopsy cases, SARS-CoV-2 RNA was detected in all nasopharyngeal samples (100%), in two oropharyngeal samples (50%), and at seven sites (41%) across 17 external body surfaces, three or more days after EM. No viral RNA was detected in anal samples. Among the five MIA cases, viral RNA was detected in two nasopharyngeal samples (40%), one oropharyngeal sample (20%), and at four sites (44%) across nine external body surfaces, three or more days after EM. The reduction in viral load before and after EM exceeded 99%in nasopharynx and oropharyngeal samples in both autopsy and MIA cases, and exceeded 94% on external body surfaces in MIA cases. Moreover, viral reduction was greater several days after EM than immediately following the procedure. These findings suggest that the combination of MIA and EM effectively reduces the detectableSARS-CoV-2 RNA in COVID-19-infected corpses. Additionally, maintaining the body for several days after EM appears to reduce the viral levels.