<p>Neonatal sepsis is an important concern in the field of neonatology, contributing significantly to morbidity and mortality among newborns worldwide. Despite progress in medical care, the accurate diagnosis and comprehension of the pathological underpinnings of neonatal sepsis continue to present challenges. Conventional diagnostic autopsy (CDA) provides unique opportunities to gain insights into the histomorphological alterations associated with neonatal sepsis. There is a paucity of literature regarding autopsy-related histomorphological features in neonatal sepsis in various organs. This narrative review aims to glean data from published literature concerning autopsy-related histomorphological findings in neonatal sepsis, which would aid in understanding organ-related pathological changes and assisting pathologists in determining the exact cause of death.</p> Graphical Abstract <p></p>