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Purpose <p>Patients with type 2 diabetes mellitus (T2DM) exhibit high morbidity and mortality despite research progress. The aim of this study was to assess the efficacy of multidisciplinary cardiometabolic outpatient clinics in medical treatment of T2DM outpatients.</p> Methods <p>A prospective, cohort study of 200 T2DM patients attending cardiometabolic, tertiary, outpatient clinics of “Sotiria” Chest Disease Hospital and Attikon Hospital was conducted. Patients underwent structured clinical evaluation at each visit by both Diabetologists and Cardiologists including cardiovascular risk assessment, lifestyle change recommendations and optimization of medical treatment based on ESC Guidelines.</p> Results <p>Our population comprised by 76% males (mean age: 62 ± 10 years; median T2DM duration: 6.5 years); also, hypertension (75%), dyslipidaemia (79%) and coronary artery disease (CAD) (45%) were the most common comorbidities. Only 21% of very high-risk patients had LDL cholesterol &lt; 55&#xa0;mg/dL at baseline and a small percentage received the novel antidiabetic agents. During follow-up (median: 5 months), significant improvement of BMI (33.3 ± 6.2 to 32.1 ± 6.05&#xa0;kg/m², <i>p</i> &lt; 0.001), HbA1c (7.85 ± 1.73% to 6.86 ± 1.05%, <i>p</i> &lt; 0.001) and LDL cholesterol (86.7 ± 33.3&#xa0;mg/dL to 60.4 ± 28.6&#xa0;mg/dL, <i>p</i> &lt; 0.001) occurred. At follow-up, 71.5% of patients received GLP-1 RA, 56% SGLT2i and 85.5% statin; 8.5% were up-titrated to high-intensity statin and 27.5% received statin plus ezetimibe. Interestingly, 78% of very-high CVD risk patients achieved LDL cholesterol &lt; 55&#xa0;mg/dL at follow-up. Comprehensive screening revealed previously unrecognized CAD, heart failure and peripheral artery disease in 31%, 13% and 8% of patients, respectively.</p> Conclusions <p>Cardiometabolic outpatient clinics improve cardiovascular risk factor profile, adherence to the Guidelines and facilitate early detection of cardiovascular complications in T2DM patients.</p>

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“Cardiometabolic outpatient clinics: evidence from collaborative academic tertiary centers-research article”

  • 期刊论文

  • 发表日期：

    2025年10月15日

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  • Emmanouil Korakas,
  • Vasiliki Tsigkou,
  • Loukia Pliouta,
  • Stamatios Lampsas,
  • Evangelos Oikonomou,
  • Aikaterini Tsatsaragkou,
  • Maria Xenou,
  • Eleni Anastasopoulou,
  • Ignatios Ikonomidis,
  • Vaia Lambadiari,
  • Gerasimos Siasos

摘要

Purpose

Patients with type 2 diabetes mellitus (T2DM) exhibit high morbidity and mortality despite research progress. The aim of this study was to assess the efficacy of multidisciplinary cardiometabolic outpatient clinics in medical treatment of T2DM outpatients.

Methods

A prospective, cohort study of 200 T2DM patients attending cardiometabolic, tertiary, outpatient clinics of “Sotiria” Chest Disease Hospital and Attikon Hospital was conducted. Patients underwent structured clinical evaluation at each visit by both Diabetologists and Cardiologists including cardiovascular risk assessment, lifestyle change recommendations and optimization of medical treatment based on ESC Guidelines.

Results

Our population comprised by 76% males (mean age: 62 ± 10 years; median T2DM duration: 6.5 years); also, hypertension (75%), dyslipidaemia (79%) and coronary artery disease (CAD) (45%) were the most common comorbidities. Only 21% of very high-risk patients had LDL cholesterol < 55 mg/dL at baseline and a small percentage received the novel antidiabetic agents. During follow-up (median: 5 months), significant improvement of BMI (33.3 ± 6.2 to 32.1 ± 6.05 kg/m², p < 0.001), HbA1c (7.85 ± 1.73% to 6.86 ± 1.05%, p < 0.001) and LDL cholesterol (86.7 ± 33.3 mg/dL to 60.4 ± 28.6 mg/dL, p < 0.001) occurred. At follow-up, 71.5% of patients received GLP-1 RA, 56% SGLT2i and 85.5% statin; 8.5% were up-titrated to high-intensity statin and 27.5% received statin plus ezetimibe. Interestingly, 78% of very-high CVD risk patients achieved LDL cholesterol < 55 mg/dL at follow-up. Comprehensive screening revealed previously unrecognized CAD, heart failure and peripheral artery disease in 31%, 13% and 8% of patients, respectively.

Conclusions

Cardiometabolic outpatient clinics improve cardiovascular risk factor profile, adherence to the Guidelines and facilitate early detection of cardiovascular complications in T2DM patients.