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Purpose <p>The purpose of this study was to identify high-risk individuals through screening for dynapenic abdominal obesity (DAO) to better mitigate adverse outcomes among type 2 diabetes (T2D) patients in the future.</p> Methods <p>This study included 530 middle-aged and older T2D patients. Demographics, nutritional and inflammatory indicators, diabetes-related features, hand grip strength (GS), and body composition were collected. Subjects were grouped by GS and estimated visceral adipose tissue area (eVATA): dynapenia/abdominal obesity (D/AO), nondynapenia/abdominal obesity (N/AO), dynapenia/nonobesity (D/N), and nondynapenia/nonobesity (N/N). Multilevel logistic and linear regression were used to analyze factors influencing DAO and its relationship with vertebral fractures, respectively.</p> Results <p>Compared with the N/N group, D/AO group patients were older and had a higher high-sensitivity C-reactive protein (hsCRP) level, homeostasis model assessment of insulin resistance (HOMA-IR), and Diabetes Complications Severity Index (DCSI). Regarding body composition and physical performance, subjects with DAO had a greater percentage of total body fat, a lower ratio of appendicular skeletal muscle mass to weight, a higher lumbar spine T score, and a slower gait speed. The risk factors for DAO included greater age and DCSI. Further regression analysis revealed a positive correlation between DAO and the Spinal Deformity Index (B [95% CI], 0.672 [0.005, 1.339]; <i>P</i> = 0.048).</p> Conclusions <p>Among middle-aged and older patients with T2D, DAO is quite common, showing a unique feature related to aging and disease. Identifying DAO may provide new hope for screening high-risk individuals with T2D in terms of functionality and health outcomes.</p>

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Dynapenic abdominal obesity: an important hallmark of metabaging in patients with type 2 diabetes

  • 期刊论文

  • 发表日期：

    2025年9月4日

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  • Yan Pi,
  • Yinghao Li,
  • Xin Ye,
  • Mei Mei,
  • Kun Liao,
  • Fengning Chuan,
  • Rong Li,
  • Bo Zhou

摘要

Purpose

The purpose of this study was to identify high-risk individuals through screening for dynapenic abdominal obesity (DAO) to better mitigate adverse outcomes among type 2 diabetes (T2D) patients in the future.

Methods

This study included 530 middle-aged and older T2D patients. Demographics, nutritional and inflammatory indicators, diabetes-related features, hand grip strength (GS), and body composition were collected. Subjects were grouped by GS and estimated visceral adipose tissue area (eVATA): dynapenia/abdominal obesity (D/AO), nondynapenia/abdominal obesity (N/AO), dynapenia/nonobesity (D/N), and nondynapenia/nonobesity (N/N). Multilevel logistic and linear regression were used to analyze factors influencing DAO and its relationship with vertebral fractures, respectively.

Results

Compared with the N/N group, D/AO group patients were older and had a higher high-sensitivity C-reactive protein (hsCRP) level, homeostasis model assessment of insulin resistance (HOMA-IR), and Diabetes Complications Severity Index (DCSI). Regarding body composition and physical performance, subjects with DAO had a greater percentage of total body fat, a lower ratio of appendicular skeletal muscle mass to weight, a higher lumbar spine T score, and a slower gait speed. The risk factors for DAO included greater age and DCSI. Further regression analysis revealed a positive correlation between DAO and the Spinal Deformity Index (B [95% CI], 0.672 [0.005, 1.339]; P = 0.048).

Conclusions

Among middle-aged and older patients with T2D, DAO is quite common, showing a unique feature related to aging and disease. Identifying DAO may provide new hope for screening high-risk individuals with T2D in terms of functionality and health outcomes.