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Purpose <p>To evaluate demographic characteristics, clinical, laboratory, imaging features, and treatment responses of boys who were diagnosed and treated for central precocious puberty (CPP).</p> Methods <p>The data were collected from pediatric endocrinology clinics in Türkiye. Patients were classified into two groups based on magnetic resonance imaging (MRI) findings, idiopathic CPP (iCPP) and organic CPP (oCPP). The oCPP group was further cathegorized into three subgroups: oCPP-confirmed, oCPP-unrelated, and oCPP-uncertain lesions.</p> Results <p>Among 232 patients, 62.9% were diagnosed with iCPP. All patients aged &lt;3 years had oCPP-confirmed lesions. Basal luteinizing hormone (LH) and total testosterone (T) levels were higher in oCPP group than in iCPP group <i>(p</i> = <i>0.004</i> and <i>p</i> = <i>0.02</i>, respectively<i>)</i>. Basal LH, basal follicle-stimulating hormone (FSH), T, and peak LH/FSH were lower in the iCPP-obese group <i>(p</i> &lt; <i>0.05)</i>. T differed significantly among the oCPP-confirmed, oCPP-unrelated, and oCPP-uncertain subgroups <i>(p</i> = <i>0.032)</i>. Among patients that reached final height (FH), the difference between target height (TH) standard deviation score (SDS) and FH SDS was higher in oCPP group than in iCPP group <i>(p</i> &lt; <i>0.05)</i>. A positive correlation was found between predicted adult height at the treatment initiation and FH <i>(r</i> = <i>0.463 p</i> = <i>0.020)</i>. Factors affecting FH were height SDS at the beginning of treatment, paternal height SDS, and TH SDS.</p> Conclusions <p>The prevelance of oCPP was found lower compared with previous literature data. Currently, there is no reliable marker to predict oCPP that would allow clinicians to safely omit MRI in iCPP cases. However, boys under 3 years of age should be carefully evaluated for potential organic causes of CPP.</p>

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Central precocious puberty in boys; diagnosis, treatment and follow-up: a nation-wide study

  • 期刊论文

  • 发表日期：

    2025年8月11日

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  • Sevinc Odabasi Gunes,
  • Merve Sakar,
  • Nursel Muratoglu Sahin,
  • Gulay Karaguzel,
  • Emine Ayca Cimbek,
  • Feyza Darendeliler,
  • Ezgi Sarban,
  • Esra Doger,
  • Ganimet Oner,
  • Zeynep Siklar,
  • Gizem Senyazar,
  • Murat Aydin,
  • Behzat Ozkan,
  • Ozlem Sangun,
  • Mesut Parlak,
  • Onur Akin,
  • Kadriye Cansu Sahin,
  • İhsan Esen,
  • Aylin Kilinc Ugurlu,
  • Gulcan Seymen,
  • Semih Bolu,
  • Elif Sobu,
  • Servan Ozalkak,
  • Emine Demet Akbas,
  • Gonul Buyukyilmaz,
  • Beray Selver Eklioglu,
  • Ahmet Ucar,
  • Pinar Kocaay,
  • Selma Tunc,
  • Serpil Bas,
  • İsmail Dundar,
  • Eda Celebi Bitkin,
  • Ayca Torel Ergur,
  • Dilek Bingol Aydin,
  • Birgul Kirel,
  • Aysun Ata,
  • Muge Atar,
  • Mehmet Isakoca,
  • Emel Hatun Aytac Kaplan,
  • Tugba Kontbay,
  • Derya Tepe,
  • Oya Ercan,
  • Mehmet Boyraz,
  • Nesibe Akyurek,
  • Edip Unal,
  • Nurhan Ozcan Murat,
  • Serkan Bilge Koca,
  • Zumrut Kocabey Sutcu,
  • Feyza Nehir Oznur Muz,
  • Semra Cetinkaya

摘要

Purpose

To evaluate demographic characteristics, clinical, laboratory, imaging features, and treatment responses of boys who were diagnosed and treated for central precocious puberty (CPP).

Methods

The data were collected from pediatric endocrinology clinics in Türkiye. Patients were classified into two groups based on magnetic resonance imaging (MRI) findings, idiopathic CPP (iCPP) and organic CPP (oCPP). The oCPP group was further cathegorized into three subgroups: oCPP-confirmed, oCPP-unrelated, and oCPP-uncertain lesions.

Results

Among 232 patients, 62.9% were diagnosed with iCPP. All patients aged <3 years had oCPP-confirmed lesions. Basal luteinizing hormone (LH) and total testosterone (T) levels were higher in oCPP group than in iCPP group (p = 0.004 and p = 0.02, respectively). Basal LH, basal follicle-stimulating hormone (FSH), T, and peak LH/FSH were lower in the iCPP-obese group (p < 0.05). T differed significantly among the oCPP-confirmed, oCPP-unrelated, and oCPP-uncertain subgroups (p = 0.032). Among patients that reached final height (FH), the difference between target height (TH) standard deviation score (SDS) and FH SDS was higher in oCPP group than in iCPP group (p < 0.05). A positive correlation was found between predicted adult height at the treatment initiation and FH (r = 0.463 p = 0.020). Factors affecting FH were height SDS at the beginning of treatment, paternal height SDS, and TH SDS.

Conclusions

The prevelance of oCPP was found lower compared with previous literature data. Currently, there is no reliable marker to predict oCPP that would allow clinicians to safely omit MRI in iCPP cases. However, boys under 3 years of age should be carefully evaluated for potential organic causes of CPP.