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Purpose <p>This study aimed to evaluate the prognostic significance of tumor deposits (TD) in patients with differentiated thyroid cancer (DTC) undergoing postoperative radioiodine (RAI) therapy. Additionally, it explored the potential role of TD in refining the TNM staging system.</p> Methods <p>A retrospective analysis was performed on 11,278 thyroid cancer patients who underwent surgery. After applying stringent inclusion and exclusion criteria, 2162 patients were included in the final analysis. The association between TD and various clinicopathological characteristics was assessed. Propensity Score Matching (PSM) was employed to minimize selection bias, comparing outcomes between TD-positive [TD(+)] and TD-negative [TD(−)] groups. Kaplan-Meier survival analysis was utilized to estimate cumulative incidence rate of excellent response (ER) to RAI therapy. Prognostic comparisons were conducted by stratifying patients based on TD and lymph node (LN) status. Furthermore, a novel staging system incorporating TD status into the N stage of the TNM system was developed, and its prognostic accuracy was evaluated.</p> Results <p>Out of the 11,278 patients, 235 (2.08%) were identified as TD(+). In the 2162 patients analyzed, TD was significantly associated with T stage, N stage, extrathyroidal invasion, cumulative RAI dose, preablative stimulated thyroglobulin (Ps-Tg) levels, lymph node metastasis (LNM) count, primary tumor multiplicity, and maximum tumor diameter. Using a (1:2) PSM strategy, 95 TD(+) patients were matched with 185 TD(−) counterparts. Kaplan-Meier analysis revealed a significant difference in treatment outcomes between TD(+) and TD(−) groups (40.0% vs. 62.7%, <i>P</i> = 0.001). When comparing LN(+)TD(−) and LN(−)TD(+), no significant difference in outcomes was observed (59.8% vs. 44.4%, <i>P</i> = 0.235). However, outcomes differed significantly between LN(+)TD(+) and LN(+)TD(−) groups (39.5% vs. 59.8%, <i>P</i> = 0.004). No significant difference was noted between LN(+)TD(+) and LN(−)TD(+) groups (39.5% vs. 44.4%, <i>P</i> = 0.974). In N0 and N1a stages, TD(+) patients had significantly poorer prognoses compared to TD(−) patients (44.4% vs. 93.8%, <i>P</i> = 0.029 and 42.4% vs. 77.6%, <i>P</i> &lt; 0.001, respectively). However, in the N1b stage, there was no significant difference between TD(+) and TD(−) groups (37.3% vs. 48.0%, <i>P</i> = 0.229). Interestingly, TD(+) patients in N0 and N1a stages exhibited outcomes comparable to N1b stage patients (44.4% vs. 44.5%, <i>P</i> = 0.603 and 42.4% vs. 44.5%, <i>P</i> = 0.108, respectively).</p> Conclusion <p>The presence of TD significantly affected the prognosis of DTC patients undergoing postoperative RAI therapy and should be considered an essential factor in assessing patient prognosis. Incorporating TD status into the TNM staging system is recommended, with TD(+) patients proposed to be classified under the N1b stage.</p>

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Prognostic impact and clinical staging adjustment of tumor deposits in postoperative radioiodine therapy for differentiated thyroid cancer

  • 期刊论文

  • 发表日期：

    2025年7月5日

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  • Lei Wang,
  • Yangdingxin Li,
  • Jing Yang,
  • Wei Shen,
  • Zhao Liu,
  • Hui Zhu,
  • Qinghua Zhang,
  • Xiancun Hou,
  • Zhiyong Li,
  • Yuan Zhu

摘要

Purpose

This study aimed to evaluate the prognostic significance of tumor deposits (TD) in patients with differentiated thyroid cancer (DTC) undergoing postoperative radioiodine (RAI) therapy. Additionally, it explored the potential role of TD in refining the TNM staging system.

Methods

A retrospective analysis was performed on 11,278 thyroid cancer patients who underwent surgery. After applying stringent inclusion and exclusion criteria, 2162 patients were included in the final analysis. The association between TD and various clinicopathological characteristics was assessed. Propensity Score Matching (PSM) was employed to minimize selection bias, comparing outcomes between TD-positive [TD(+)] and TD-negative [TD(−)] groups. Kaplan-Meier survival analysis was utilized to estimate cumulative incidence rate of excellent response (ER) to RAI therapy. Prognostic comparisons were conducted by stratifying patients based on TD and lymph node (LN) status. Furthermore, a novel staging system incorporating TD status into the N stage of the TNM system was developed, and its prognostic accuracy was evaluated.

Results

Out of the 11,278 patients, 235 (2.08%) were identified as TD(+). In the 2162 patients analyzed, TD was significantly associated with T stage, N stage, extrathyroidal invasion, cumulative RAI dose, preablative stimulated thyroglobulin (Ps-Tg) levels, lymph node metastasis (LNM) count, primary tumor multiplicity, and maximum tumor diameter. Using a (1:2) PSM strategy, 95 TD(+) patients were matched with 185 TD(−) counterparts. Kaplan-Meier analysis revealed a significant difference in treatment outcomes between TD(+) and TD(−) groups (40.0% vs. 62.7%, P = 0.001). When comparing LN(+)TD(−) and LN(−)TD(+), no significant difference in outcomes was observed (59.8% vs. 44.4%, P = 0.235). However, outcomes differed significantly between LN(+)TD(+) and LN(+)TD(−) groups (39.5% vs. 59.8%, P = 0.004). No significant difference was noted between LN(+)TD(+) and LN(−)TD(+) groups (39.5% vs. 44.4%, P = 0.974). In N0 and N1a stages, TD(+) patients had significantly poorer prognoses compared to TD(−) patients (44.4% vs. 93.8%, P = 0.029 and 42.4% vs. 77.6%, P < 0.001, respectively). However, in the N1b stage, there was no significant difference between TD(+) and TD(−) groups (37.3% vs. 48.0%, P = 0.229). Interestingly, TD(+) patients in N0 and N1a stages exhibited outcomes comparable to N1b stage patients (44.4% vs. 44.5%, P = 0.603 and 42.4% vs. 44.5%, P = 0.108, respectively).

Conclusion

The presence of TD significantly affected the prognosis of DTC patients undergoing postoperative RAI therapy and should be considered an essential factor in assessing patient prognosis. Incorporating TD status into the TNM staging system is recommended, with TD(+) patients proposed to be classified under the N1b stage.