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Purpose <p>Plasma atherogenic index is a major risk factor for cardiac metabolic disease, but the long-term effect of high cumAIP on the risk of CMD development is unclear. Therefore, we aimed to determine the effect of cumulative plasma atherogenic index exposure on cardiac metabolic disease.</p> Methods <p>A total of 44,603 subjects who participated in the Kailuan Study health examination in 2006, 2008 and 2010, had complete blood lipid data, and had no previous history of CMD or cancer were selected. The cumulative AIP index was calculated as a weighted sum (value × time) of the average AIP index during each time interval. The population was divided into four groups according to the cumAIP quartile level. Cox proportional hazards regression model and restricted cubic spline regression model were used to further analyze the effect of cumAIP on the risk of CMD. Due to the competing risk of death, the traditional Cox model may cause bias on the risk of CMD. Therefore, death was regarded as a competing event, and the Fine-Gray model was used to analyze the difference in the risk of CMD in different cumAIP groups.</p> Results <p>During a mean follow-up period of (9.79 ± 2.60) years, 7674 (17.21%) of 44603 participants developed CMD. After adjusting for potential confounding factors, Cox regression analysis showed that compared with group Q1, the risk of CMD in group Q2, Q3, and Q4 increased by 26% (HR = 1.26, 95%CI: 1.17–1.36) and 44% (HR = 1.44, 95%CI: 1.17–1.36), respectively. 95%CI: 1.34–1.55), 83% (HR = 1.83, 95%CI: 1.70–1.96). Each standard deviation increase in the risk of myocardial infarction, revascularization, ischemic stroke, and type 2 diabetes was 1.25 (1.15, 1.36), 1.19 (1.12, 1.26), 1.08 (1.03, 1.13), and 1.35 (1.31, 1.39) for cumAIP, respectively.</p> Conclusions <p>There was a significant association between high levels of cumAIP exposure and higher risk of CMD. The effect of long-term exposure to high levels of cumAIP on increasing the risk of CMD was more obvious in the low-risk population.</p>

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Association between the cumulative exposure to atherogenic index of plasma and risk of cardiometabolic diseases: a prospective cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月27日

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  • Meixiao Wang,
  • Shihe Liu,
  • Luqing Liu,
  • Xinran Wen,
  • Yicheng Liao,
  • Hongmin Liu,
  • Shouling Wu,
  • Yuntao Wu

摘要

Purpose

Plasma atherogenic index is a major risk factor for cardiac metabolic disease, but the long-term effect of high cumAIP on the risk of CMD development is unclear. Therefore, we aimed to determine the effect of cumulative plasma atherogenic index exposure on cardiac metabolic disease.

Methods

A total of 44,603 subjects who participated in the Kailuan Study health examination in 2006, 2008 and 2010, had complete blood lipid data, and had no previous history of CMD or cancer were selected. The cumulative AIP index was calculated as a weighted sum (value × time) of the average AIP index during each time interval. The population was divided into four groups according to the cumAIP quartile level. Cox proportional hazards regression model and restricted cubic spline regression model were used to further analyze the effect of cumAIP on the risk of CMD. Due to the competing risk of death, the traditional Cox model may cause bias on the risk of CMD. Therefore, death was regarded as a competing event, and the Fine-Gray model was used to analyze the difference in the risk of CMD in different cumAIP groups.

Results

During a mean follow-up period of (9.79 ± 2.60) years, 7674 (17.21%) of 44603 participants developed CMD. After adjusting for potential confounding factors, Cox regression analysis showed that compared with group Q1, the risk of CMD in group Q2, Q3, and Q4 increased by 26% (HR = 1.26, 95%CI: 1.17–1.36) and 44% (HR = 1.44, 95%CI: 1.17–1.36), respectively. 95%CI: 1.34–1.55), 83% (HR = 1.83, 95%CI: 1.70–1.96). Each standard deviation increase in the risk of myocardial infarction, revascularization, ischemic stroke, and type 2 diabetes was 1.25 (1.15, 1.36), 1.19 (1.12, 1.26), 1.08 (1.03, 1.13), and 1.35 (1.31, 1.39) for cumAIP, respectively.

Conclusions

There was a significant association between high levels of cumAIP exposure and higher risk of CMD. The effect of long-term exposure to high levels of cumAIP on increasing the risk of CMD was more obvious in the low-risk population.