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Skin assessment in congenital untreated isolated GH deficiency

  • 期刊论文

  • 发表日期：

    2024年5月4日

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  • Cynthia S. Barros-Oliveira,
  • Maria Joseli Melo de Jesus,
  • Viviane C. Campos,
  • Roberto Salvatori,
  • Adriano Antunes de Souza Araújo,
  • Roberto Fernandes Soares Neto,
  • Andrzej Bartke,
  • Vanderlan O. Batista,
  • Augusto Schneider,
  • Keila R. Villar-Gouy,
  • Michal M. Masternak,
  • Ângela C. Leal,
  • Lucas B. Santos,
  • Carla R. P. Oliveira,
  • Elenilde G. Santos,
  • Davi A. Oliveira Simões,
  • Bruno de Santana Silva,
  • Manuel H. Aguiar-Oliveira

摘要

Purpose

The separation between the inside and outside through the skin was fundamental for the evolution of prevertebrates, which grow through extrapituitary circuits, to vertebrates, which grow through the somatotrophic axis, namely pituitary growth hormone (GH). and circulating IGF1.Individuals with untreated isolated growth hormone (GH) deficiency (IGHD) due to a mutation in the GH-releasing hormone receptor (GHRH) gene, residing in Itabaianinha, Brazil, are vulnerable to skin cancer and have reduced sweating. However other aspects of their skin physiology are still unknown. Our objectives were to evaluate the number of skin cancers, skin aging, and functional aspects of the skin in this IGHD cohort.

Methods

Twenty-six IGHD individuals and 26 controls matched by age, sex, ethnicity, and occupation were submitted to a biochemical, dermatological and a functional skin assessment by the Multi Probe Adapter Cutometer® MPA 580.

Results

There was no difference in the number of skin cancers and in the degrees of photodamage between the groups. The melanin content in the forearm was similar between the groups but was lower in the buttocks (p = 0.005), as well as skin resistance (p < 0.0001) and elasticity (p = 0.003), lower in the IGHD. There was no difference in hydration and sebum content between the two groups.

Conclusion

IGHD is apparently associated with a neutral profile in terms of skin cancer and photodamage, with similar melanin on the forearm and lower buttocks, lower skin resistance and elasticity, with hydration and sebum similar to controls.