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<p>Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by complex pathophysiology and significant clinical challenges. Emerging research emphasizes the crucial role of neuropeptides in GBM and its influence on tumor progression, immune modulation, and therapy resistance. This review highlighted the importance of neuropeptides and their receptors in maintaining brain homeostasis and the glioblastoma tumor microenvironment. We discussed new therapeutic frontiers, including neuropeptide receptors as therapeutic targets, renin-angiotensin system, peptide receptor modulation, targeted cytotoxic analogs (such as Bombesin and Somatostatin), and advances in targeted radiotherapy. The review highlighted the potential of neuropeptide-based targeted therapies to improve GBM patient outcomes and suggests future research directions. This underscores the importance of targeting neuropeptide-related pathways for innovative therapeutic strategies in GBM, aiming to enhance patient prognosis and effective treatment.</p>

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Neuropeptide Signaling in Glioblastoma: A Comprehensive Review of the Current State and Future Direction

  • 期刊论文

  • 发表日期：

    2025年4月14日

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  • Shahid Afridi,
  • Mohd Muzzammil,
  • Intezar Ali,
  • Mehdi H. Shahi

摘要

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by complex pathophysiology and significant clinical challenges. Emerging research emphasizes the crucial role of neuropeptides in GBM and its influence on tumor progression, immune modulation, and therapy resistance. This review highlighted the importance of neuropeptides and their receptors in maintaining brain homeostasis and the glioblastoma tumor microenvironment. We discussed new therapeutic frontiers, including neuropeptide receptors as therapeutic targets, renin-angiotensin system, peptide receptor modulation, targeted cytotoxic analogs (such as Bombesin and Somatostatin), and advances in targeted radiotherapy. The review highlighted the potential of neuropeptide-based targeted therapies to improve GBM patient outcomes and suggests future research directions. This underscores the importance of targeting neuropeptide-related pathways for innovative therapeutic strategies in GBM, aiming to enhance patient prognosis and effective treatment.