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<p>Autoimmune hepatitis (AIH) is typically a chronic, inflammatory, and progressive liver disease of autoimmune origin. Currently, two recognized types are identified in clinical practice: type 1 and type 2. The disease can occur in all geographic regions and racial/ethnic groups worldwide, but shows marked variations. This pattern reflects a complex interplay between genetic factors and environmental triggers. In this review, we aim to examine the geoepidemiological features of AIH and explore how these features relate to its etiopathogenesis, providing an integrated analysis of this complex condition. Our work may shed light on the initiation and progression of AIH, as well as its treatment and prevention.</p>

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The Geoepidemiology of Autoimmune Hepatitis

  • 期刊论文

  • 发表日期：

    2026年2月11日

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  • Yang Li,
  • Xiangzhen Meng,
  • Patrick S. C. Leung,
  • M. Eric Gershwin,
  • Diego Vergani,
  • Junmin Song

摘要

Autoimmune hepatitis (AIH) is typically a chronic, inflammatory, and progressive liver disease of autoimmune origin. Currently, two recognized types are identified in clinical practice: type 1 and type 2. The disease can occur in all geographic regions and racial/ethnic groups worldwide, but shows marked variations. This pattern reflects a complex interplay between genetic factors and environmental triggers. In this review, we aim to examine the geoepidemiological features of AIH and explore how these features relate to its etiopathogenesis, providing an integrated analysis of this complex condition. Our work may shed light on the initiation and progression of AIH, as well as its treatment and prevention.