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<p>MPL (myeloproliferative leukemia virus) is a type I transmembrane glycoprotein acting as the receptor for thrombopoietin (TPO). Increasing evidence indicates that MPL is essential for stem cell maintenance and megakaryopoiesis. Activating mutations in MPL have been identified as the major driver mutations of myeloproliferative neoplasms (MPNs) characterized by excessive proliferation of multiple lineages. Given its dual role in hematopoiesis and MPN pathogenesis, studies of MPL reveal the imbalance between stem cell homeostasis and malignant proliferation. Here, we summarize MPL’s physiological functions and pathogenic roles, with the aim to provide novel insights into disease mechanisms and potential therapeutic strategies.</p> Graphical Abstract <p></p>

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Thrombopoietin Receptor MPL in Hematopoiesis and Myeloproliferative Neoplasms: Physiological Roles and Pathogenic Mechanisms

  • 期刊论文

  • 发表日期：

    2026年4月27日

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  • Shujing Zhang,
  • Muhammad Sameer Ashaq,
  • Miaomiao Xu,
  • Meiqi Guo,
  • Lingling Wang,
  • Zhuoran Li,
  • Yi Wang,
  • Yufeng Huang,
  • Yuan Li,
  • Baobing Zhao

摘要

MPL (myeloproliferative leukemia virus) is a type I transmembrane glycoprotein acting as the receptor for thrombopoietin (TPO). Increasing evidence indicates that MPL is essential for stem cell maintenance and megakaryopoiesis. Activating mutations in MPL have been identified as the major driver mutations of myeloproliferative neoplasms (MPNs) characterized by excessive proliferation of multiple lineages. Given its dual role in hematopoiesis and MPN pathogenesis, studies of MPL reveal the imbalance between stem cell homeostasis and malignant proliferation. Here, we summarize MPL’s physiological functions and pathogenic roles, with the aim to provide novel insights into disease mechanisms and potential therapeutic strategies.

Graphical Abstract