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<p>Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting millions worldwide. The complexity of PD has hindered the development of accurate disease models. Induced pluripotent stem cells (iPSCs), derived from patient-specific cells, offer a promising platform for modeling PD. This review discusses the development of PD models using iPSCs from different patient sources, focusing on 2D and 3D culture systems. We also explore the integration of iPSCs with advanced technologies like multi-omics, tissue engineering, and gene editing, and their potential to drive breakthroughs in disease modeling. Co-culture systems of iPSC-derived neurons and glial cells provide insights into cell-cell interactions in PD, while 3D brain region-specific organoids enhance understanding of interregional disease processes. Advances in multi-omics and gene editing have further propelled iPSC-based disease modeling, offering new avenues for investigating disease mechanisms and therapeutic screening.</p> Graphical Abstract <p>This review focuses on previously discovered mechanisms of PD and examines mechanisms explored in iPSC-based disease models. The illustrations in this figure were created with BioRender (BioRender.com).</p> <p></p>

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Induced Pluripotent Stem Cells Derived Cellular Models for Investigating Parkinson’s Disease Pathogenesis and Drug Screening

  • 期刊论文

  • 发表日期：

    2025年6月30日

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  • Jihong Liu,
  • Wanlin Zhao,
  • Zijuan Zhang,
  • Xilei Ai,
  • Bing Cao,
  • Zhenqiang Zhang,
  • Dongrui Ma

摘要

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting millions worldwide. The complexity of PD has hindered the development of accurate disease models. Induced pluripotent stem cells (iPSCs), derived from patient-specific cells, offer a promising platform for modeling PD. This review discusses the development of PD models using iPSCs from different patient sources, focusing on 2D and 3D culture systems. We also explore the integration of iPSCs with advanced technologies like multi-omics, tissue engineering, and gene editing, and their potential to drive breakthroughs in disease modeling. Co-culture systems of iPSC-derived neurons and glial cells provide insights into cell-cell interactions in PD, while 3D brain region-specific organoids enhance understanding of interregional disease processes. Advances in multi-omics and gene editing have further propelled iPSC-based disease modeling, offering new avenues for investigating disease mechanisms and therapeutic screening.

Graphical Abstract

This review focuses on previously discovered mechanisms of PD and examines mechanisms explored in iPSC-based disease models. The illustrations in this figure were created with BioRender (BioRender.com).