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<p>Curcumin is a potent anticancer agent as it inhibits cell proliferation, tumor growth, and promotes cell death. It works by suppressing multiple cellular signaling pathways and inhibiting cell growth, but its poor oral bioavailability and low stability are a concern. CoFe<sub>2</sub>O<sub>4</sub> (CF) nanoparticles were synthesized by the w/o microemulsion method, and their surface functionalization was performed by using PEG (CFP) and silica (CFS) nanoparticles (NPs) by the solvothermal technique. For structural and functional group analyses, bare and surface functionalized NPs were characterized by XRD, VSM, FTIR, and TEM, whereas for surface charge characteristics, zeta potential was measured. The bare and functionalized nanoparticles were then loaded with curcumin. The efficacy of nanocarriers was evaluated for antibacterial, antioxidant, and anticancer properties on the 4T-1 cancer cell line. The curcumin release behavior was studied, and the kinetic data was evaluated for pseudo-first order, pseudo second-order , Elovich and intraparticle models. Further, in-vivo effects were explored on Swiss albino mice for wound healing, hepatoprotective, and hematology. After performing various biological applications, it was found that drug-loaded CF, CFP and CFS nanocarriers showed a decrease in cell viability and increased cytotoxicity as compared to curcumin alone. In addition, curcumin-loaded samples showed promising results for wound healing, hematology, and hepatoprotective studies.</p>

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Multifunctional Curcumin Nanoparticles: Oncolytic, Radical Scavenging, Regenerative, Hepatoprotective, and Bactericidal Effects

  • 期刊论文

  • 发表日期：

    2026年3月13日

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  • Huzaifa Hanif,
  • Shahzad Hussain,
  • Umer Rashid,
  • Tafail Akbar Mughal,
  • Muhammad Naeem Ahmad,
  • Muhammad Waseem

摘要

Curcumin is a potent anticancer agent as it inhibits cell proliferation, tumor growth, and promotes cell death. It works by suppressing multiple cellular signaling pathways and inhibiting cell growth, but its poor oral bioavailability and low stability are a concern. CoFe2O4 (CF) nanoparticles were synthesized by the w/o microemulsion method, and their surface functionalization was performed by using PEG (CFP) and silica (CFS) nanoparticles (NPs) by the solvothermal technique. For structural and functional group analyses, bare and surface functionalized NPs were characterized by XRD, VSM, FTIR, and TEM, whereas for surface charge characteristics, zeta potential was measured. The bare and functionalized nanoparticles were then loaded with curcumin. The efficacy of nanocarriers was evaluated for antibacterial, antioxidant, and anticancer properties on the 4T-1 cancer cell line. The curcumin release behavior was studied, and the kinetic data was evaluated for pseudo-first order, pseudo second-order , Elovich and intraparticle models. Further, in-vivo effects were explored on Swiss albino mice for wound healing, hepatoprotective, and hematology. After performing various biological applications, it was found that drug-loaded CF, CFP and CFS nanocarriers showed a decrease in cell viability and increased cytotoxicity as compared to curcumin alone. In addition, curcumin-loaded samples showed promising results for wound healing, hematology, and hepatoprotective studies.