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<p>The metabolism of tumor cells exerts a great influence on the tumor microenvironment (TME) of solid tumors and antitumor immune responses. Targeting molecules from the TME is an exciting strategy to overcome the ability of solid tumors to escape immunity and immunotherapies. In this sense, this manuscript delves into the complex and sometimes antagonizing role of amino acids in the TME, regulating both tumor cells and immune cells’ biology. Understanding the specific effects of different amino acids in distinct tumors can direct compelling strategies to improve antitumor therapies, especially immunotherapies.</p>

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Amino Acids as Targets for Immunotherapy against Solid Tumors

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月26日

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  • Karine Vitória Viana da Costa,
  • Gabriel Antero Passos,
  • Rodrigo Jardim Soares Botelho,
  • Marina Sobreira Vieira Ruza,
  • Geovane Dias-Lopes,
  • Rafael Cardoso Maciel Costa Silva

摘要

The metabolism of tumor cells exerts a great influence on the tumor microenvironment (TME) of solid tumors and antitumor immune responses. Targeting molecules from the TME is an exciting strategy to overcome the ability of solid tumors to escape immunity and immunotherapies. In this sense, this manuscript delves into the complex and sometimes antagonizing role of amino acids in the TME, regulating both tumor cells and immune cells’ biology. Understanding the specific effects of different amino acids in distinct tumors can direct compelling strategies to improve antitumor therapies, especially immunotherapies.