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<p>Cardiovascular diseases (CVDs) are a serious global health burden. Flavonoids are polyphenolic compounds with strong antioxidant properties and significant capabilities to reduce oxidative stress, a key factor in CVD development. This study investigates the effect of ethanolic extract of <i>Mentha × piperita</i>, a rich source of flavonoids, on heart disease in rats. Heart disease was experimentally induced by administering 1% hydrogen peroxide (H₂O₂) for 21 days. Twenty-five male rats were divided into five groups: control, H₂O₂-treated, and three groups treated with different concentrations of flavonoid extract (100, 150, and 200&#xa0;mg/kg/day). Biochemical tests showed that the obtained flavonoid reduced serum ALT activity (<i>p</i> &lt; 0.05) and enhanced lipid profiles by lowering total cholesterol (TC), triglycerides (TG), and low-density lipoprotein (LDL). On the other hand, the high-density lipoprotein (HDL) has significantly increased. The outcomes demonstrated that the antioxidant activity of flavonoids plays an important role in decreasing oxidative stress and protecting against H₂O₂-induced cardiovascular damage. The findings highlight the translational potential of <i>Mentha</i>-derived flavonoids as natural therapeutic agents for improving lipid metabolism and reducing cardiovascular risk in humans.</p>

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Flavonoid-Rich Extracts from Mentha Piperita and their Novel Role in ALT Modulation in a Cardiovascular Disease Rat Model

  • 期刊论文

  • 发表日期：

    2025年11月27日

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  • Nuha Ali Hadi Al-samarrie,
  • Huda Ghazi Naser,
  • Suror A. Mahdi,
  • Rasha Saad Jwad,
  • Mohammed Basil Anwer,
  • Zamzam Alhuwaymil,
  • Sohad A. Alshareef,
  • Mohammed S.S. Alyami,
  • Mohammed H. Al-Mashhadani,
  • Great Iruoghene Edo

摘要

Cardiovascular diseases (CVDs) are a serious global health burden. Flavonoids are polyphenolic compounds with strong antioxidant properties and significant capabilities to reduce oxidative stress, a key factor in CVD development. This study investigates the effect of ethanolic extract of Mentha × piperita, a rich source of flavonoids, on heart disease in rats. Heart disease was experimentally induced by administering 1% hydrogen peroxide (H₂O₂) for 21 days. Twenty-five male rats were divided into five groups: control, H₂O₂-treated, and three groups treated with different concentrations of flavonoid extract (100, 150, and 200 mg/kg/day). Biochemical tests showed that the obtained flavonoid reduced serum ALT activity (p < 0.05) and enhanced lipid profiles by lowering total cholesterol (TC), triglycerides (TG), and low-density lipoprotein (LDL). On the other hand, the high-density lipoprotein (HDL) has significantly increased. The outcomes demonstrated that the antioxidant activity of flavonoids plays an important role in decreasing oxidative stress and protecting against H₂O₂-induced cardiovascular damage. The findings highlight the translational potential of Mentha-derived flavonoids as natural therapeutic agents for improving lipid metabolism and reducing cardiovascular risk in humans.