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<p>Inflammatory bowel disease (IBD), which encompasses Crohn’s disease (CD) and ulcerative colitis (UC), is an inflammatory condition influenced by genetic, environmental, microbial, and immunological factors. Recent studies emphasize the significant roles of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) as essential components of competing endogenous RNA (ceRNA) networks in IBD. Non-coding RNAs (ncRNAs) are often dysregulated in IBD, affecting inflammation, immune responses, and the integrity of the epithelial barrier. lncRNA–miRNA interactions function as regulatory centers that influence signaling pathways crucial for sustaining intestinal homeostasis. Disruptions in lncRNA–miRNA interactions damage epithelial integrity, promote inflammation, and drive disease progression. These non-coding RNAs’ stability and specificity in biological fluids make them potential non-invasive biomarkers for early diagnosis and disease monitoring. Targeting lncRNA–miRNA interactions present a new therapeutic approach to restore intestinal barrier integrity and maintain immunological balance. Despite recent advancements, further research is needed to translate these findings into clinically applicable diagnostic tools and therapies. This review provides an overview of lncRNA–miRNA–mRNA interactions in IBD, emphasizing their significance as essential components of ceRNA networks. Also, this review explores how crosstalk modulates immune regulation and epithelial function, evaluating the potential of these interactions as diagnostic and therapeutic targets. It highlights ceRNA networks and incorporates spatial omics technologies, setting it apart from previous reviews.</p>

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ceRNA Network Dynamics in Inflammatory Bowel Disease: The LncRNA–miRNA–mRNA Axis in Intestinal Homeostasis and Inflammation

  • 期刊论文

  • 发表日期：

    2025年12月6日

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  • Rofayda Ihab,
  • Mona M. Saber,
  • Ahmed S. Fouad,
  • Ahmed A. El-Sherif,
  • Mohamed A. M. Atia

摘要

Inflammatory bowel disease (IBD), which encompasses Crohn’s disease (CD) and ulcerative colitis (UC), is an inflammatory condition influenced by genetic, environmental, microbial, and immunological factors. Recent studies emphasize the significant roles of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) as essential components of competing endogenous RNA (ceRNA) networks in IBD. Non-coding RNAs (ncRNAs) are often dysregulated in IBD, affecting inflammation, immune responses, and the integrity of the epithelial barrier. lncRNA–miRNA interactions function as regulatory centers that influence signaling pathways crucial for sustaining intestinal homeostasis. Disruptions in lncRNA–miRNA interactions damage epithelial integrity, promote inflammation, and drive disease progression. These non-coding RNAs’ stability and specificity in biological fluids make them potential non-invasive biomarkers for early diagnosis and disease monitoring. Targeting lncRNA–miRNA interactions present a new therapeutic approach to restore intestinal barrier integrity and maintain immunological balance. Despite recent advancements, further research is needed to translate these findings into clinically applicable diagnostic tools and therapies. This review provides an overview of lncRNA–miRNA–mRNA interactions in IBD, emphasizing their significance as essential components of ceRNA networks. Also, this review explores how crosstalk modulates immune regulation and epithelial function, evaluating the potential of these interactions as diagnostic and therapeutic targets. It highlights ceRNA networks and incorporates spatial omics technologies, setting it apart from previous reviews.